Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties

Toxicology in Vitro : an International Journal Published in Association with BIBRA
S AzamS M Hadi

Abstract

It is believed that anticancer and apoptosis inducing properties of green tea are mediated by it's polyphenolic constituents particularly catechins. A number of reports have shown that green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) is among the most effective chemopreventive and apoptosis-inducing agents present in the beverage. Plant polyphenols are naturally occurring antioxidants but they also exhibit prooxidant properties. Over the last several years we have shown that various classes of plant polyphenols including flavonoids, curcuminoids and tannins are capable of catalyzing oxidative DNA cleavage particularly in the presence of transition metal ions such as copper and iron. With a view to understand the chemical basis of various pharmacological properties of green tea, in this paper we have compared the prooxidant properties of green tea polyphenols--EGCG and EC ((-)-epicatechin). The rate of oxidative DNA degradation as well as hydroxyl radical and superoxide anion formation was found to be greater in the case of EGCG as compared with EC. It was also shown that copper mediated oxidation of EC and EGCG possibly leads to the formation of polymerized polyphenols. Further, it was indicated that copper oxidized c...Continue Reading

References

Nov 1, 1990·Carcinogenesis·A RahmanJ H Parish
Nov 1, 1987·Biochemical Pharmacology·G J Quinlan, J M Gutteridge
Jun 1, 1987·Archives of Biochemistry and Biophysics·I Naseem, S M Hadi
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW C Willett
Jun 5, 1996·Journal of the National Cancer Institute·H Mukhtar
Mar 21, 1998·Cancer Letters·H Ahsan, S M Hadi
Jan 6, 1999·Neuroscience Letters·S SinghS M Hadi
May 5, 1999·International Journal of Urology : Official Journal of the Japanese Urological Association·D Sato

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Citations

Mar 29, 2014·Oxidative Medicine and Cellular Longevity·Sandhya KhuranaT C Tai
Aug 19, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Deniz BagdasMine Sibel Gurun
Jan 19, 2011·Journal of Proteomics·Angelo D'AlessandroLello Zolla
Jan 10, 2012·Nutrition Reviews·Christopher Masterjohn, Richard S Bruno
Jul 1, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Husain Y KhanSheikh M Hadi
Dec 19, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·Raman ChawlaG N Qazi
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tait D ShanafeltNeil E Kay
Aug 11, 2011·Journal of Pharmacy & Bioallied Sciences·Raman ChawlaRakesh Kumar Sharma
Sep 24, 2011·Analytical Chemistry·Ashraf G MadianFred E Regnier
Oct 12, 2012·Journal of Indian Society of Periodontology·Anirban ChatterjeeMahtab Alam
Jul 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gökçe TanerNurşen Başaran
Jan 16, 2014·Journal of Food Science and Technology·Fan WenjiaoZhang Yongkui
Feb 9, 2010·Journal of Medicinal Food·Thomas A RadewiczKaren S Katula
Oct 23, 2012·Cell Biochemistry and Biophysics·Chao SunZhen-hua Wang
Oct 2, 2013·Pharmacognosy Magazine·Hasan Kılıçgün, Gülden Göksen
Jan 1, 2007·Toxicology Mechanisms and Methods·H BabichE R Ravkin
Jul 30, 2014·Toxicology and Applied Pharmacology·Sushma Reddy GundalaRitu Aneja
Jun 3, 2014·Journal of Proteomics·Verónica BolañosEsther Ramírez-Moreno
Nov 15, 2011·Nutrition Research·Katalin RévészLaura Konta
Apr 13, 2011·Journal of Inorganic Biochemistry·Nathan R PerronJulia L Brumaghim
Jan 5, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsueh-Fang WangShur-Hueih Cherng
Sep 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Dharmendra Kumar Maurya, Thomas Paul Asir Devasagayam
Sep 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M A PapiezW Wiczkowski
Sep 25, 2010·Chemico-biological Interactions·Ivonne M C M RietjensMarelle G Boersma
Jul 1, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wissem BhouriLeila Chekir-Ghedira
Jun 30, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Harvey BabichAlyssa G Schuck
Mar 10, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Woon-Gye ChungClaudia S Maier
Dec 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeanine L MarnewickWentzel C A Gelderblom
May 23, 2008·The Journal of Nutritional Biochemistry·Ana Belén Granado-SerranoSonia Ramos

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