Propagating Motor Cortical Dynamics Facilitate Movement Initiation.

Neuron
Karthikeyan BalasubramanianNicholas G Hatsopoulos

Abstract

Voluntary movement initiation involves the modulations of large groups of neurons in the primary motor cortex (M1). Yet similar modulations occur during movement planning when no movement occurs. Here, we show that a sequential spatiotemporal pattern of excitability propagates across M1 prior to the movement initiation in one of two oppositely oriented directions along the rostro-caudal axis. Using spatiotemporal patterns of intracortical microstimulation, we find that reaction time increases significantly when stimulation is delivered against, but not with, the natural propagation direction. Functional connections among M1 units emerge at movement that are oriented along the same rostro-caudal axis but not during movement planning. Finally, we show that beta amplitude profiles can more accurately decode muscle activity when they conform to the natural propagating patterns. These findings provide the first causal evidence that large-scale, propagating patterns of cortical excitability are behaviorally relevant and may be a necessary component of movement initiation.

References

Sep 1, 1978·Journal of Neurophysiology·H C KwanY C Wong
Sep 1, 1978·Brain : a Journal of Neurology·K C GatterT P Powell
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·V N Murthy, E E Fetz
Jan 1, 1991·Experimental Brain Research·S Hocherman, S P Wise
Jan 1, 1983·International Review of Neurobiology·M H Chase
Oct 18, 1996·Science·D P Hanes, J D Schall
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·J C PrechtlD Kleinfeld
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
May 11, 2002·Journal of Sports Sciences·Masaya HirashimaTatsuyuki Ohtsuki
Feb 13, 2004·Brain : a Journal of Neurology·Andrea A KühnPeter Brown
May 28, 2004·Journal of Neurophysiology·Michael C ParkPaul D Cheney
May 29, 2004·Cerebral Cortex·Ana SolodkinSteven L Small
Jul 28, 2004·Journal of Neurophysiology·Nicholas HatsopoulosJohn G O'Leary
Jan 19, 2005·The European Journal of Neuroscience·David WilliamsPeter Brown
Jul 21, 2006·Journal of Neurophysiology·Mark M ChurchlandKrishna V Shenoy
Sep 29, 2006·Journal of Neurophysiology·Mark M Churchland, Krishna V Shenoy
Nov 23, 2006·Nature Neuroscience·Doug RubinoNicholas G Hatsopoulos
Apr 6, 2007·Journal of Neural Engineering·Russell S WitteDaryl R Kipke
Jul 6, 2007·Neuron·Weifeng XuJian-young Wu
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dennis TkachNicholas G Hatsopoulos
Dec 7, 2007·Neuron·Isabelle FerezouCarl C H Petersen
Jan 1, 1994·IEEE Transactions on Neural Networks·M T Hagan, M B Menhaj
Jan 23, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hanna Mäki, Risto J Ilmoniemi
Apr 2, 2011·PLoS Computational Biology·Sanggyun KimEmery N Brown
Jun 2, 2011·Frontiers in Human Neuroscience·Kazutaka TakahashiNicholas G Hatsopoulos
Nov 11, 2011·Frontiers in Psychology·Cyril R PernetGuillaume A Rousselet
Nov 15, 2011·Neuron·Nicholas G Hatsopoulos, Aaron J Suminski
Jun 23, 2012·Nature·Mark M ChurchlandKrishna V Shenoy
Jul 31, 2012·Neuron·Tatsuo K SatoMatteo Carandini
Jan 8, 2013·Current Biology : CB·Ganesh VigneswaranAlexander Kraskov
Feb 4, 2014·Nature Neuroscience·Matthew T KaufmanKrishna V Shenoy
Jan 21, 2015·Neuron·Theodoros P ZanosChristopher C Pack
May 23, 2015·Nature Communications·Kazutaka TakahashiNicholas G Hatsopoulos
Dec 27, 2016·Frontiers in Neural Circuits·Yaoyao HaoThomas G Brochier

❮ Previous
Next ❯

Citations

Nov 13, 2020·Nature Reviews. Neuroscience·Sadra Sadeh, Claudia Clopath
Oct 30, 2020·Neuron·Arto Nurmikko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Related Papers

BioRxiv : the Preprint Server for Biology
Karthikeyan BalasubramanianNicholas G Hatsopoulos
Neuroscience and Biobehavioral Reviews
Cathy M StinearW D Byblow
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nicholas G HatsopoulosYali Amit
© 2021 Meta ULC. All rights reserved