Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Propagation of blood clotting in the complex biochemical network of hemostasis is described by a simple mechanism

Abstract

References

Highly sensitive peptide-4-methylcoumaryl-7-amide substrates for blood-clotting proteases and trypsin

Flow through a venous valve and its implication for thrombus formation

Mathematical analysis of activation thresholds in enzyme-catalyzed positive feedbacks: application to the feedbacks of blood coagulation

Electrical turbulence in three-dimensional heart muscle

Coagulation on biomaterials in flowing blood: some theoretical considerations

Reaction complexity of flowing human blood

Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition

Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse

Tissue factor: in at the start...and the finish?

Microfluidic systems: high radial acceleration in microvortices

Functional thrombomodulin deficiency causes enhanced thrombus growth in a murine model of carotid artery thrombosis

Minimal functional model of hemostasis in a biomimetic microfluidic system

Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively

A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis

Modular chemical mechanism predicts spatiotemporal dynamics of initiation in the complex network of hemostasis

Citations

High content evaluation of shear dependent platelet function in a microfluidic flow assay.

Using chemistry and microfluidics to understand the spatial dynamics of complex biological networks.

Blood flow controls coagulation onset via the positive feedback of factor VII activation by factor Xa.

Microfluidic models of vascular functions

Spatial aspects of blood coagulation: two decades of research on the self-sustained traveling wave of thrombin

Protective value of a folkloric medicinal plant extract against mortality and hemorrhage in a life-threatening renal trauma model

Hemostasis and thrombosis beyond biochemistry: roles of geometry, flow and diffusion

Using microfluidics to understand the effect of spatial distribution of tissue factor on blood coagulation

Can we build synthetic, multicellular systems by controlling developmental signaling in space and time?

Use of a novel haemostatic agent: ankaferd blood stopper in conjunctival incisions

Confinement regulates complex biochemical networks: initiation of blood clotting by "diffusion acting".

Global haemostasis assays, from bench to bedside

Rate of mixing controls rate and outcome of autocatalytic processes: theory and microfluidic experiments with chemical reactions and blood coagulation.

Robust self-healing hydrogels assisted by cross-linked nanofiber networks

Threshold response of initiation of blood coagulation by tissue factor in patterned microfluidic capillaries is controlled by shear rate

A simple microfluidic method to select, isolate, and manipulate single-cells in mechanical and biochemical assays

Indirect Rapid Prototyping: Opening Up Unprecedented Opportunities in Scaffold Design and Applications

A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A.

Evaluation of the hemostatic and histopathological effects of Ankaferd Blood Stopper in experimental liver injury in rats

Evaluation of a new hemostatic agent Ankaferd Blood Stopper in experimental liver laceration

Microfluidics in Haemostasis: A Review

A nanoliter-scale open chemical reactor

Additively Manufactured Self-Healing Structures with Embedded Healing Agent Reservoirs

Estimation of Diabetic Retinal Microaneurysm Perfusion Parameters Based on Computational Fluid Dynamics Modeling of Adaptive Optics Scanning Laser Ophthalmoscopy.

Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels

In vitro flow-based assay: From simple toward more sophisticated models for mimicking hemostasis and thrombosis.

Effects of shear rate on propagation of blood clotting determined using microfluidics and numerical simulations

Neutrophil extracellular traps induced by pro-inflammatory cytokines enhance procoagulant activity in NASH patients.

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