Propagation of spontaneous electrical activity in the ex vivo human uterus.

Pflügers Archiv : European journal of physiology
Nienke P M KuijstersChiara Rabotti

Abstract

Contractions of the non-pregnant uterus play a key role in fertility. Yet, the electrophysiology underlying these contractions is poorly understood. In this paper, we investigate the presence of uterine electrical activity and characterize its propagation in unstimulated ex vivo human uteri. Multichannel electrohysterographic measurements were performed in five freshly resected human uteri starting immediately after hysterectomy. Using an electrode grid externally and an electrode array internally, measurements were performed up to 24 h after hysterectomy and compared with control. Up to 2 h after hysterectomy, we measured biopotentials in all included uteri. The median root mean squared (RMS) values of the external measurements ranged between 3.95 μV (interquartile range (IQR) 2.41-14.18 μV) and 39.4 μV (interquartile range (IQR) 10.84-105.64 μV) and were all significantly higher than control (median RMS of 1.69 μV, IQR 1.13-3.11 μV), consisting of chicken breast meat. The RMS values decreased significantly over time. After 24 h, the median RMS (1.27 μV, IQR 0.86-3.04 μV) was comparable with the control (1.69 μV, IQR 1.13-3.11 μV, p = 0.125). The internal measurements showed a comparable pattern over time, but overall lower am...Continue Reading

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Citations

Jul 4, 2020·Pflügers Archiv : European journal of physiology·Wim J Lammers

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Methods Mentioned

BETA
hysterectomy
surgical resection

Software Mentioned

SPSS
MATLAB
PolyBench

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