Propensity for Bistability of Bursting and Silence in the Leech Heart Interneuron

Frontiers in Computational Neuroscience
Tatiana Dashevskiy, Gennady Cymbalyuk

Abstract

The coexistence of neuronal activity regimes has been reported under normal and pathological conditions. Such multistability could enhance the flexibility of the nervous system and has many implications for motor control, memory, and decision making. Multistability is commonly promoted by neuromodulation targeting specific membrane ionic currents. Here, we investigated how modulation of different ionic currents could affect the neuronal propensity for bistability. We considered a leech heart interneuron model. It exhibits bistability of bursting and silence in a narrow range of the leak current parameters, conductance (g leak ) and reversal potential (E leak ). We assessed the propensity for bistability of the model by using bifurcation diagrams. On the diagram (g leak ,E leak ), we mapped bursting and silent regimes. For the canonical value ofE leak we determined the range ofg leak which supported the bistability. We use this range as an index of propensity for bistability. We investigated how this index was affected by alterations of ionic currents. We systematically changed their conductances, one at a time, and built corresponding bifurcation diagrams in parameter planes of the maximal conductance of a given current and the...Continue Reading

References

Jan 1, 1979·Physiological Reviews·G S StentR L Calabrese
Jul 1, 1979·Biophysical Journal·E N Best
Jan 1, 1985·Experimental Brain Research·J Hounsgaard, O Kiehn
Jan 1, 1989·Annual Review of Neuroscience·P A Getting
Jul 1, 1989·Acta Physiologica Scandinavica·T Eken, O Kiehn
Jan 1, 1984·Experimental Brain Research·J HounsgaardO Kiehn
May 1, 1995·Bulletin of Mathematical Biology·R BertramA Sherman
Aug 1, 1994·Current Biology : CB·E Marder
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·E MarderJ Golowasch
Jun 1, 1997·Journal of Neurophysiology·C F HsiaoS H Chandler
Aug 15, 1998·Journal of Neurophysiology·R H Lee, C J Heckman
Jan 23, 1999·Current Opinion in Neurobiology·O Kiehn, T Eken
May 3, 2000·The European Journal of Neuroscience·K P CarlinR M Brownstone
Aug 12, 2000·Journal of Neurophysiology·J Foss, J Milton
Feb 13, 2001·Brain Research Bulletin·J F Perrier, J Hounsgaard
Jul 10, 2001·Journal of Computational Neuroscience·A A HillR L Calabrese
Aug 29, 2001·Journal of Computational Neuroscience·P J Hahn, D M Durand
Nov 15, 2002·Nature·Alexei V EgorovAngel A Alonso
Jun 5, 2003·Chaos·Robert J. Butera
Jul 31, 2003·The European Journal of Neuroscience·Simon P AikenNicholas Dale
Mar 3, 2004·Molecular Interventions·Douglas A BaylissEdmund M Talley
Aug 28, 2004·Journal of Neurophysiology·Pablo FuentealbaMircea Steriade
Oct 23, 2004·The Journal of Physiology·Vincenzo CrunelliStuart W Hughes
Jan 25, 2005·Nature Neuroscience·Yonatan LoewensteinMichael Häusser
Mar 1, 2005·The European Journal of Neuroscience·Philip M Larkman, Emma M Perkins
Apr 15, 2005·Journal of Computational Neuroscience·Gennady Cymbalyuk, Andrey Shilnikov
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Andrey ShilnikovGennady Cymbalyuk
Aug 12, 2005·Journal of Neurophysiology·Anne-Elise Tobin, Ronald L Calabrese
Dec 6, 2005·Neuroscience·D Durstewitz, J K Seamans
Aug 10, 2006·Journal of Computational Neuroscience·Joël TabakJohn Rinzel
Sep 8, 2006·Journal of Neurophysiology·David PaydarfarJohn R Clay
Oct 10, 2006·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Flavio Fröhlich, Maxim Bazhenov
Oct 31, 2006·Journal of Computational Neuroscience·Sharmila VenugopalDavid H Terman

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Citations

Jul 24, 2018·Frontiers in Computational Neuroscience·Fleur ZeldenrustBernhard Englitz

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