Propensity score-based comparison of the graft failure risk between kidney transplant recipients of standard and expanded criteria donor grafts: Toward increasing the pool of marginal donors

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Anne-Hélène QuerardEtienne Dantan

Abstract

From a prospective and multicentric French cohort, we proposed an external validation study for the expanded criteria donor (ECD), based on 4833 kidney recipients transplanted for the first time between 2000 and 2014. We estimated the subject-specific effect from a multivariable Cox model. We confirmed a 1.75-fold (95% confidence interval [CI] 1.53-2.00, P < .0001) increase in graft failure risk if a given patient received an ECD graft compared to a graft from a donor with standard criteria (standard criteria donor [SCD]). Complementarily, we estimated the population-average effect using propensity scores. We estimated a 1.34-fold (95% CI 1.09-1.64, P = .0049) increase in graft failure risk among ECD patients receiving an ECD graft compared to receiving a SCD graft. With a 10-year follow-up, it corresponded to a decrease of 8 months of the mean time to graft failure due to ECD transplantation (95% CI 2-14 months). The population-average relative risk due to ECD transplantation and the corresponding absolute effect seem finally not so high. Regarding the increase of quality of life in transplantation, our study constitutes an argument to extend the definition of marginality by considering more grafts at high risk and thereby enl...Continue Reading

References

Aug 1, 1996·Controlled Clinical Trials·M Schemper, T L Smith
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Scott L NybergMark D Stegall
May 26, 2004·Computer Methods and Programs in Biomedicine·Stephen R Cole, Miguel A Hernán
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jesse D ScholdHerwig-Ulf Meier-Kriesche
Aug 6, 2009·Statistical Methods in Medical Research·Per Kragh Andersen, Maja Pohar Perme
Feb 9, 2010·American Journal of Epidemiology·Daniel Westreich, Stephen R Cole
Mar 3, 2011·European Heart Journal·Georg Heinze, Peter Jüni
Apr 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A M Reeves-DanielB I Freedman
Sep 3, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TonelliJ Gill
Feb 7, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Miklos Z MolnarKamyar Kalantar-Zadeh
Jun 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Joshua D MezrichAnthony M D'Alessandro
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K J WoodsideR S Sung
Jun 17, 2014·Clinical Transplantation·Benjamin PhilosopheRaghava B Munivenkatappa
Dec 19, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Maggie K M MaGermaine Wong
Jan 13, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Anne-Hélène QuerardFlorence Gillaizeau
Jan 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HartA K Israni

❮ Previous
Next ❯

Citations

Sep 5, 2019·Current HIV/AIDS Reports·Jean BothaCaroline T Tiemessen
Sep 12, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Guilherme Palhares Aversa SantosHenrique Mochida Takase
May 31, 2018·Transplantation·Jeffrey L VealeThomas D Mone
Aug 28, 2018·World Journal of Transplantation·Giacomo ColussiFabio Rosario Salerno
Dec 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker AssfalgStephan Kemmner
Feb 3, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Christian KuhnDaniel Sidler
Jun 23, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Paloma Barreda MonteolivaEmilio Rodrigo Calabria

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.