Propensity score weighting under limited overlap and model misspecification.

Statistical Methods in Medical Research
Yunji ZhouLaine Thomas

Abstract

Propensity score weighting methods are often used in non-randomized studies to adjust for confounding and assess treatment effects. The most popular among them, the inverse probability weighting, assigns weights that are proportional to the inverse of the conditional probability of a specific treatment assignment, given observed covariates. A key requirement for inverse probability weighting estimation is the positivity assumption, i.e. the propensity score must be bounded away from 0 and 1. In practice, violations of the positivity assumption often manifest by the presence of limited overlap in the propensity score distributions between treatment groups. When these practical violations occur, a small number of highly influential inverse probability weights may lead to unstable inverse probability weighting estimators, with biased estimates and large variances. To mitigate these issues, a number of alternative methods have been proposed, including inverse probability weighting trimming, overlap weights, matching weights, and entropy weights. Because overlap weights, matching weights, and entropy weights target the population for whom there is equipoise (and with adequate overlap) and their estimands depend on the true propensit...Continue Reading

References

Sep 1, 1986·International Journal of Epidemiology·S Greenland, J M Robins
Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Sep 24, 2004·Pharmacoepidemiology and Drug Safety·Donald B Rubin
Apr 21, 2006·American Journal of Epidemiology·M Alan BrookhartTil Stürmer
Jun 23, 2006·Journal of Epidemiology and Community Health·Miguel A Hernán, James M Robins
Jun 3, 2008·Statistical Science : a Review Journal of the Institute of Mathematical Statistics·Anastasios A Tsiatis, Marie Davidian
Aug 7, 2008·American Journal of Epidemiology·Stephen R Cole, Miguel A Hernán
Dec 17, 2008·Psychological Methods·Joseph L Schafer, Joseph Kang
Feb 9, 2010·American Journal of Epidemiology·Daniel Westreich, Stephen R Cole
Oct 30, 2010·Statistical Methods in Medical Research·Maya L PetersenMark J van der Laan
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Daniel WestreichTil Stürmer
Apr 13, 2011·PloS One·Brian K LeeElizabeth A Stuart
Aug 2, 2013·The International Journal of Biostatistics·Liang Li, Tom Greene
Sep 12, 2013·Circulation. Cardiovascular Quality and Outcomes·M Alan BrookhartTil Stürmer
Dec 18, 2014·American Journal of Epidemiology·Romain PirracchioMark van der Laan
Mar 20, 2016·American Journal of Epidemiology·Miguel A Hernán, James M Robins
May 14, 2018·Journal of the American Heart Association·Toby RogersRon Waksman
Jun 21, 2018·Statistical Methods in Medical Research·Huzhang MaoTom Greene
Jul 12, 2018·Statistical Methods in Medical Research·Cheng JuMark J van der Laan
Aug 7, 2019·Pharmacoepidemiology and Drug Safety·Robert J GlynnTil Stürmer
Jan 1, 2016·Communications for Statistical Applications and Methods·Joseph KangPeter M Steiner
Feb 14, 2020·International Journal of Public Health·André MoserMarcel Zwahlen

❮ Previous
Next ❯

Citations

May 25, 2021·Clinical Pharmacology and Therapeutics·Julien KirchgesnerSebastian Schneeweiss
Jun 16, 2021·Multivariate Behavioral Research·Alvaro FuentesAlexander Robitzsch
Aug 29, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Akira OkadaTakashi Kadowaki
Sep 11, 2021·Neurology·Peter C AustinMoira K Kapral

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy

Software Mentioned

IPW

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Statistical Methods in Medical Research
Huzhang MaoTom Greene
BMJ : British Medical Journal
Mohammad Ali Mansournia, Douglas G Altman
© 2021 Meta ULC. All rights reserved