Propensity to obesity impacts the neuronal response to energy imbalance

Frontiers in Behavioral Neuroscience
Marc-Andre CornierJason R Tregellas

Abstract

The mechanisms responsible for the propensity to gain weight or remain normal weight are poorly understood. The objective of this study was to study the neuronal response to visual food cues during short-term energy imbalance in healthy adults recruited as obesity-resistant (OR) or obesity-prone (OP) based on self-identification, body mass index, and personal/family weight history. Twenty-five OR and 28 OP subjects were studied in underfed (UF) and overfed (OF) as compared to eucaloric (EU) conditions in a randomized crossover design. Each study phase included a 3-day run-in diet, 1 day of controlled feeding (basal energy needs for EU, 40% above/below basal energy needs for OF/UF), and a test day. On the test day, fMRI was performed in the acute fed stated (30 min after a test meal) while subjects viewed images of foods of high hedonic value and neutral non-food objects. Measures of appetite and hormones were also performed before and every 30 min after the test meal. UF was associated with significantly increased activation of insula, somatosensory cortex, inferior and medial prefrontal cortex (PFC), parahippocampus, precuneus, cingulate, and visual cortex in OR. However, UF had no impact in OP. As a result, UF was associated ...Continue Reading

References

Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Nov 1, 1982·Psychological Medicine·D M GarnerP E Garfinkel
Feb 1, 1995·Diabetes Care·D B AllisonF X Pi-Sunyer
Oct 1, 1996·Brain Research. Brain Research Reviews·J R Augustine
Aug 5, 1999·Journal of Computer Assisted Tomography·L M LevyD Schellinger
Sep 3, 2004·The European Journal of Neuroscience·Elanor C HintonAdrian M Owen
Dec 14, 2004·NeuroImage·Marcia Levin PelchatJ Daniel Ragland
Aug 22, 2006·Metabolism: Clinical and Experimental·Marc-Andre CornierDaniel H Bessesen
Oct 9, 2007·The American Journal of Clinical Nutrition·Marc-Andre CornierJason R Tregellas
Jun 24, 2008·The Journal of Clinical Investigation·Michael RosenbaumJoy Hirsch
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H ZhengH-R Berthoud
Sep 29, 2009·Nutrition & Metabolism·Rebecca L AdochioMarc-Andre Cornier
Oct 9, 2009·The European Journal of Neuroscience·Anthony P GoldstoneJimmy D Bell
Sep 10, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S CarnellA Geliebter
Sep 29, 2011·The International Journal of Behavioral Nutrition and Physical Activity·Kyle S BurgerSusan L Johnson
Sep 12, 2012·Appetite·Jason SmucnyJason R Tregellas
Nov 24, 2012·Metabolism: Clinical and Experimental·Cecilia C L WangMarc-Andre Cornier
Dec 12, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S L SchmidtD H Bessesen
Jan 15, 2013·Physiology & Behavior·Marc-Andre CornierJason R Tregellas

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Citations

Feb 4, 2016·The Lancet. Diabetes & Endocrinology·Haiko SchlöglMichael Stumvoll
Jun 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·George A Bray, Claude Bouchard
Dec 15, 2017·Obesity·Kristina T LeggetJason R Tregellas
Nov 20, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Liya KeremFranziska Plessow
Nov 7, 2019·Obesity Science & Practice·A M van OpstalH Pijl
Nov 7, 2020·Physiology & Behavior·Kristina T LeggetJason R Tregellas

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Methods Mentioned

BETA
ELISA

Software Mentioned

SigmaStat
SPSS
SPM8
Statistical Parametric Mapping 8

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