Abstract
The mechanisms responsible for the propensity to gain weight or remain normal weight are poorly understood. The objective of this study was to study the neuronal response to visual food cues during short-term energy imbalance in healthy adults recruited as obesity-resistant (OR) or obesity-prone (OP) based on self-identification, body mass index, and personal/family weight history. Twenty-five OR and 28 OP subjects were studied in underfed (UF) and overfed (OF) as compared to eucaloric (EU) conditions in a randomized crossover design. Each study phase included a 3-day run-in diet, 1 day of controlled feeding (basal energy needs for EU, 40% above/below basal energy needs for OF/UF), and a test day. On the test day, fMRI was performed in the acute fed stated (30 min after a test meal) while subjects viewed images of foods of high hedonic value and neutral non-food objects. Measures of appetite and hormones were also performed before and every 30 min after the test meal. UF was associated with significantly increased activation of insula, somatosensory cortex, inferior and medial prefrontal cortex (PFC), parahippocampus, precuneus, cingulate, and visual cortex in OR. However, UF had no impact in OP. As a result, UF was associated ...Continue Reading
References
Jan 1, 1985·Journal of Psychosomatic Research·A J Stunkard, S Messick
Nov 1, 1982·Psychological Medicine·D M GarnerP E Garfinkel
Feb 1, 1995·Diabetes Care·D B AllisonF X Pi-Sunyer
Oct 1, 1996·Brain Research. Brain Research Reviews·J R Augustine
Aug 5, 1999·Journal of Computer Assisted Tomography·L M LevyD Schellinger
Sep 3, 2004·The European Journal of Neuroscience·Elanor C HintonAdrian M Owen
Nov 6, 2004·Appetite·Marc-Andre CornierDaniel H Bessesen
Dec 14, 2004·NeuroImage·Marcia Levin PelchatJ Daniel Ragland
Aug 22, 2006·Metabolism: Clinical and Experimental·Marc-Andre CornierDaniel H Bessesen
Jun 15, 2007·NeuroImage·Yvonne RothemundBurghard F Klapp
Oct 9, 2007·The American Journal of Clinical Nutrition·Marc-Andre CornierJason R Tregellas
Apr 17, 2008·NeuroImage·Luke E StoeckelJames E Cox
Jun 24, 2008·The Journal of Clinical Investigation·Michael RosenbaumJoy Hirsch
Nov 26, 2008·Behavioural Brain Research·Nicolette SiepAnita Jansen
Jun 19, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H ZhengH-R Berthoud
Jul 25, 2009·Obesity·Laura E MartinCary R Savage
Jul 29, 2009·PloS One·Marc-Andre CornierJason R Tregellas
Aug 14, 2009·The American Journal of Clinical Nutrition·Jeanne M McCafferyRena R Wing
Sep 29, 2009·Nutrition & Metabolism·Rebecca L AdochioMarc-Andre Cornier
Oct 9, 2009·The European Journal of Neuroscience·Anthony P GoldstoneJimmy D Bell
Nov 30, 2010·NeuroImage·L N van der LaanP A M Smeets
Sep 10, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S CarnellA Geliebter
Sep 29, 2011·The International Journal of Behavioral Nutrition and Physical Activity·Kyle S BurgerSusan L Johnson
Oct 18, 2011·Cell Metabolism·Akila De SilvaWaljit S Dhillo
Mar 28, 2012·Physiology & Behavior·D W TangA Dagher
Apr 24, 2012·Obesity·Stacy L SchmidtDaniel H Bessesen
Sep 12, 2012·Appetite·Jason SmucnyJason R Tregellas
Nov 24, 2012·Metabolism: Clinical and Experimental·Cecilia C L WangMarc-Andre Cornier
Dec 12, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S L SchmidtD H Bessesen
Jan 15, 2013·Physiology & Behavior·Marc-Andre CornierJason R Tregellas
Feb 14, 2013·Appetite·Elizabeth A ThomasMarc-Andre Cornier
Jan 2, 2014·Appetite·James Kennedy, Anastasia Dimitropoulos
Jan 1, 2014·Frontiers in Nutrition·Kirrilly M PurseyTracy L Burrows
Citations
Jan 8, 2016·Nutrients·R Drew SayerWayne W Campbell
Jul 7, 2015·Appetite·Alice V ElyMichael R Lowe
Feb 4, 2016·The Lancet. Diabetes & Endocrinology·Haiko SchlöglMichael Stumvoll
Aug 21, 2016·Obesity·R Drew SayerWayne W Campbell
Nov 5, 2016·Scientific Reports·R Alan HarrisKjersti M Aagaard
Jan 20, 2019·Pediatric Obesity·Allison L B ShapiroJason R Tregellas
Jan 24, 2020·Obesity·Tanya M HallidayDaniel H Bessesen
Jun 10, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·George A Bray, Claude Bouchard
Dec 15, 2017·Obesity·Kristina T LeggetJason R Tregellas
Nov 20, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Liya KeremFranziska Plessow
Sep 22, 2017·Journal of Physical Therapy Science·Young-Han Park, Jung-Ho Lee
Nov 7, 2019·Obesity Science & Practice·A M van OpstalH Pijl
Nov 7, 2020·Physiology & Behavior·Kristina T LeggetJason R Tregellas