Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat

Neuroscience Letters
S SweitzerJoyce A DeLeo

Abstract

The development of painful peripheral neuropathy is a dose-limiting side effect of numerous cancer chemotherapeutic agents. The present study utilized a rodent model of vincristine-induced neuropathy to determine whether a glial modulating agent, propentofylline, could attenuate vincristine-induced mechanical allodynia. Intravenous vincristine administered on days 1 through 5 and days 8 through 11 produced mechanical allodynia using 2 and 12 g von Frey filaments. Lumbar spinal cord from animals on day 15 expressed mild bilateral microglial and astrocytic activation as compared to saline-treated animals. Daily intraperitoneal propentofylline at 10 mg/kg attenuated mechanical allodynia induced by vincristine administration. In addition, propentofylline was found to decrease spinal microglial and astrocytic activation on day 15. These data suggest that central glial cells may play an important role in the development of painful neuropathy following vincristine administration.

References

Apr 1, 1994·Cancer Treatment Reviews·M K Tuxen, S W Hansen
Nov 5, 1997·Annals of the New York Academy of Sciences·P SchubertS Ferroni
Jul 3, 1998·European Journal of Pharmacology·J Sawynok
Oct 9, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vasudeva RaghavendraJoyce A DeLeo
May 18, 2004·Neurochemistry International·Julie Wieseler-FrankLinda R Watkins

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Citations

Mar 16, 2011·Journal of Natural Medicines·Arunachalam Muthuraman, Nirmal Singh
Oct 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nicolas AuthierAlain Eschalier
Jan 8, 2008·Neuron Glia Biology·Annemarie LedeboerKirk W Johnson
May 31, 2008·British Journal of Anaesthesia·A Dray
Jun 26, 2013·British Journal of Anaesthesia·A Ellis, D L H Bennett
Nov 3, 2010·The Journal of Clinical Investigation·Gillian Burgess, Dic Williams
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng WeiRonald Dubner
Mar 13, 2014·ILAR Journal·Ahmet Höke, Mitali Ray
Dec 18, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Dun LingluYu Jianqiang
Jun 28, 2007·Expert Opinion on Investigational Drugs·Annemarie LedeboerKirk W Johnson
Jul 22, 2008·Rheumatic Diseases Clinics of North America·Andy Dray
Jul 30, 2008·The European Journal of Neuroscience·Mark R HutchinsonLinda R Watkins
Dec 25, 2009·Fundamental & Clinical Pharmacology·Amteshwar Singh JaggiNirmal Singh
Jul 10, 2009·Pediatric Blood & Cancer·Andrew Moore, Ross Pinkerton
Jul 26, 2008·Brain Research·Juan P CataPatrick M Dougherty
Sep 7, 2011·Experimental Neurology·Margarita Calvo, David L H Bennett
Jan 7, 2014·Trends in Neurosciences·Amy M Smith, Mike Dragunow
Jul 16, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arunachalam MuthuramanAmteshwar Singh Jaggi
Nov 15, 2011·Toxicology·Amteshwar Singh Jaggi, Nirmal Singh
Oct 21, 2009·Neuron·Stephen B McMahon, Marzia Malcangio
Mar 27, 2013·European Journal of Pharmacology·Rikke Rie Hansen, Marzia Malcangio
Jan 31, 2012·Toxicology and Industrial Health·Venkata Rathina Kumar ThiagarajanNirmal Singh
Jan 21, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Justin G LeesGila Moalem-Taylor
Nov 21, 2012·Journal of Korean Medical Science·Hue Jung ParkDong Eon Moon
Sep 3, 2013·Current Opinion in Neurology·Manuel DieziThierry Kuntzer
Feb 24, 2018·Pharmacological Reports : PR·Anil KumarArti Singh
Jan 5, 2020·Drug and Chemical Toxicology·Terumasa ChibaKenji Abe
Aug 25, 2020·Brain : a Journal of Neurology·Lubin ChenSulayman D Dib-Hajj
Jul 26, 2016·Experimental and Therapeutic Medicine·Seunguk BangSang Rok Jeong
May 21, 2019·Critical Reviews in Microbiology·Shanshan ZhongChuansheng Zhao
Mar 13, 2021·Progress in Neurobiology·Rabia Bouali-BenazzouzPascal Fossat
Jul 26, 2017·Behavioural Brain Research·Ian N JohnstonMark R Hutchinson

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