Proper Gcn5 histone acetyltransferase expression is required for normal anteroposterior patterning of the mouse skeleton.

Development, Growth & Differentiation
Wenchu LinSharon Y R Dent

Abstract

Histone acetylation plays important roles in gene regulation. However, the functions of individual histone acetyltransferases (HATs) in specific developmental transcription programs are not well defined. To define the functions of Gcn5, a prototypical HAT, during mouse development, we have created a series of mutant Gcn5 alleles. Our previous work revealed that deletion of Gcn5 leads to embryonic death soon after gastrulation. Embryos homozygous for point mutations in the catalytic center of Gcn5 survive longer, but die soon after E16.0 and exhibit defects in cranial neural tube closure. Embryos bearing a hypomorphic Gcn5(flox(neo)) allele also exhibit neural closure defects and die at or soon after birth. We report here that Gcn5(flox(neo)/flox(neo)) and Gcn5(flox(neo)/Delta) embryos exhibit anterior homeotic transformations in lower thoracic and lumbar vertebrae. These defects are accompanied by a shift in the anterior expression boundary of Hoxc8 and Hoxc9. These data provide the first evidence that Gcn5 contributes to Hox gene regulation and is required for normal anteroposterior patterning of the mouse skeleton.

References

Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Oct 1, 1994·Trends in Genetics : TIG·D Duboule, G Morata
Aug 1, 1995·Trends in Genetics : TIG·R Paro
Feb 1, 1996·Developmental Biology·P W Holland, J Garcia-Fernàndez
Oct 1, 1996·Molecular Biology and Evolution·E PopodiR A Raff
Aug 1, 1996·Mechanisms of Development·N M van der LugtJ Deschamps
Jan 15, 1997·Developmental Biology·F Chen, M R Capecchi
Feb 1, 1997·Molecular Human Reproduction·B Favier, P Dollé
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D YuS J Korsmeyer
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·B D StrahlC D Allis
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·T YamauchiY Nakatani
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·R Marmorstein
Mar 15, 2002·Current Opinion in Genetics & Development·Jeffrey A Simon, John W Tamkun
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bradley E BernsteinStuart L Schreiber
Sep 28, 2002·Nature·Helena Santos-RosaTony Kouzarides
Nov 28, 2002·Molecular Cell·Thomas A MilneJay L Hess
Mar 22, 2003·Science·Kathrin PlathYi Zhang
Dec 9, 2003·Nature Cell Biology·Robert SchneiderTony Kouzarides
May 7, 2004·Development·Craig T MillerCharles B Kimmel
May 25, 2004·Genes & Development·Séverine Chambeyron, Wendy A Bickmore
Jul 1, 2005·Nature·Tae Hoon KimBing Ren
Mar 1, 2006·Current Opinion in Genetics & Development·Wenchu Lin, Sharon Y R Dent

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Citations

Oct 18, 2011·Human Molecular Genetics·Yi Chun ChenSharon Y R Dent
Aug 12, 2014·Epigenomics·Li Wang, Sharon Y R Dent
Oct 1, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ping ZhangYongsheng Zhou
Nov 18, 2009·The Journal of Pathology·Andrew J Copp, Nicholas D E Greene
Feb 22, 2013·Journal of Neurodevelopmental Disorders·Junlin LiXiaocai Gao
Jun 16, 2011·PloS One·Andrew J ChildsPhilippa T K Saunders
Sep 26, 2014·PLoS Genetics·Akihiko MutoThomas F Schilling
Nov 30, 2016·Developmental Biology·Sunita WarrierIrene E Zohn
May 26, 2017·Acta Biochimica Et Biophysica Sinica·Ji Hoon OhMyoung Hee Kim
Apr 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beixue GaoDeyu Fang
Nov 6, 2018·Nature Reviews. Genetics·Bilal N Sheikh, Asifa Akhtar
Dec 11, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R L AshbyJ E Adams
Sep 10, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xuan XuJing Yu Liu
Nov 11, 2020·Cancer Research·Aimee T FarriaSharon Y R Dent
Jul 31, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Evangelia KoutelouSharon Y R Dent
Dec 30, 2020·International Journal of Biological Macromolecules·K GomathiN Selvamurugan
Nov 26, 2019·Developmental Cell·Lacey J LuenseShelley L Berger

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