Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons

Journal of Neurophysiology
Cathleen BradlerPeter Kloppenburg

Abstract

Ca(2+)-activated potassium currents [IK(Ca)] are an important link between the intracellular signaling system and the membrane potential, which shapes intrinsic electrophysiological properties. To better understand the ionic mechanisms that mediate intrinsic firing properties of olfactory uniglomerular projection neurons (uPNs), we used whole cell patch-clamp recordings in an intact adult brain preparation of the male cockroach Periplaneta americana to analyze IK(Ca) In the insect brain, uPNs form the principal pathway from the antennal lobe to the protocerebrum, where centers for multimodal sensory processing and learning are located. In uPNs the activation of IK(Ca) was clearly voltage and Ca(2+) dependent. Thus under physiological conditions IK(Ca) is strongly dependent on Ca(2+) influx kinetics and on the membrane potential. The biophysical characterization suggests that IK(Ca) is generated by big-conductance (BK) channels. A small-conductance (SK) channel-generated current could not be detected. IK(Ca) was sensitive to charybdotoxin (CTX) and iberiotoxin (IbTX) but not to apamin. The functional role of IK(Ca) was analyzed in occlusion experiments under current clamp, in which portions of IK(Ca) were blocked by CTX or IbTX....Continue Reading

References

Aug 1, 1989·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R KanzakiJ G Hildebrand
May 1, 1974·The Journal of General Physiology·C M Armstrong, F Bezanilla
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Nov 1, 1994·Trends in Neurosciences·H U Dodt, W Zieglgänsberger
Jul 1, 1995·The American Journal of Physiology·M L GarciaG J Kaczorowski
Jan 1, 1996·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·A R MercerJ G Hildebrand
Jun 1, 1996·Journal of Bioenergetics and Biomembranes·G J KaczorowskiM L Garcia
Jan 1, 1997·Annual Review of Neuroscience·J G Hildebrand, G M Shepherd
Aug 4, 1998·Current Opinion in Neurobiology·C VergaraJ P Adelman
Feb 27, 1999·Annals of the New York Academy of Sciences·W C Lemon, W M Getz
Oct 6, 1999·Current Opinion in Neurobiology·N J Strausfeld, J G Hildebrand
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·G HeimbeckR F Stocker
Mar 29, 2002·The Journal of Comparative Neurology·Kouji YasuyamaFriedrich-Wilhelm Schürmann
May 17, 2002·Progress in Neurobiology·Pankaj Sah, E S Louise Faber
Nov 28, 2002·The Journal of Comparative Neurology·Hiroshi NishinoMakoto Mizunami
Apr 3, 2003·Nature Reviews. Neuroscience·Martin Heisenberg
Sep 16, 2003·Neuron·Mark StopferGilles Laurent
Oct 15, 2003·Neuron·George J AugustineKeiko Tanaka
Dec 20, 2003·Science·Rachel I WilsonGilles Laurent
Apr 7, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·E S Louise Faber, Pankaj Sah
Jun 24, 2004·The Journal of Biological Chemistry·Morten Grunnet, Walter A Kaufmann
Aug 24, 2004·European Journal of Pharmacology·Bernard FiorettiLuigi Catacuzzeno
Sep 21, 2004·Nature Reviews. Neuroscience·Martin Stocker
Sep 29, 2004·Neuron·Ronald L Davis
Nov 12, 2005·Journal of Neurophysiology·Christopher G Perk, Alison R Mercer
Dec 17, 2005·Pharmacology & Therapeutics·Srinivas GhattaStephen T O'Rourke
Jun 17, 2006·Annual Review of Neuroscience·Rachel I Wilson, Zachary F Mainen
Aug 16, 2006·Neuron·Bede M BroomeGilles Laurent
Nov 23, 2006·Nature Reviews. Neuroscience·Lawrence SalkoffAguan Wei
May 18, 2007·Annual Review of Neuroscience·Leslie B Vosshall, Reinhard F Stocker
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Cornelia I Bargmann

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Jan 25, 2021·Cell and Tissue Research·Debora Fuscà, Peter Kloppenburg

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