PMID: 11332572May 3, 2001Paper

Properties and substrate of slow pathway exposed with a compact node targeted fast pathway ablation in rabbit atrioventricular node

Journal of Cardiovascular Electrophysiology
L J LinK Khalife

Abstract

The properties and substrates of slow and fast AV nodal pathway remain unclear. This applies particularly to the slow pathway (SP), which is largely concealed by fast pathway (FP) conduction. We designed a new FP ablation approach that exposes the SP over the entire cycle length range and allows for its independent characterization and ablation. Premature stimulation was performed before and after FP ablation with 5.4 +/- 1.9 lesions (300-microm diameter each; overall lesion size 1.4 +/- 0.5 mm) targeting the junction between perinodal and compact node tissues in seven rabbit heart preparations. The resulting SP recovery curve and control curve had the same maximum nodal conduction time (165 +/- 22 msec vs 164 +/- 24 msec; P = NS) and effective refractory period (101 +/- 10 msec vs 100 +/- 9 msec; P = NS). The two curves covered the same cycle length range. However, the SP curve was shifted up with respect to control one at intermediate and long cycle lengths and thus showed a longer minimum nodal conduction time (81 +/- 15 msec vs 66 +/- 10 msec; P < 0.01) and functional refractory period (180 +/- 11 msec vs 170 +/- 12 msec; P < 0.05). The SP curve was continuous and closely fitted by a single exponential function. Small local...Continue Reading

Citations

Dec 18, 2003·Journal of Cardiovascular Electrophysiology·Marie Claude ReidRafik Tadros
Jan 14, 2004·Clinical Physiology and Functional Imaging·Shaowen LiuS Bertil Olsson
Mar 19, 2004·Journal of Cardiovascular Electrophysiology·Jacques Billette
Nov 3, 2007·Pacing and Clinical Electrophysiology : PACE·Demosthenes G Katritsis
Sep 4, 2010·Journal of Cardiovascular Electrophysiology·Domenico CorradiSergio Callegari
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Demosthenes G KatritsisA John Camm
Nov 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jacques Billette, Rafik Tadros
May 31, 2019·Pacing and Clinical Electrophysiology : PACE·Jacques Billette, Rafik Tadros

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