PMID: 2112369Jun 1, 1990Paper

Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase

Archives of Biochemistry and Biophysics
B Brüne, E G Lapetina

Abstract

A novel ADP-ribosyltransferase is present in the cytosolic fraction of various cells. The kinetic behavior and physical properties of this enzyme's activity are clearly distinguished from other known cytosolic ADP-ribosyltransferases. Agents that release nitric oxide, such as sodium nitroprusside, greatly stimulated this activity, although this effect was dependent on the presence of intact thiol groups. Dithiothreitol, reduced glutathione, or cysteine was needed for activation of the enzyme, while N-ethylmaleimide inhibited enzyme activity. High concentrations of phosphate had a slight stimulatory effect, while high concentrations of sodium chloride and thiocyanate were inhibitory. ATP also inhibited this activity. This cytosolic ADP-ribosyltransferase is clearly distinguished from other known and characterized cytosolic transferases. Its activation by biologically active nitric oxide suggests an important role for this enzymatic activity.

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Jul 13, 2000·Microscopy Research and Technique·I B KimM H Chun
Sep 1, 1994·Molecular and Cellular Biochemistry·L J McDonald, J Moss
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