PMID: 7082625May 1, 1982Paper

Properties of a novel series of inhibitors of rumen methanogenesis; in vitro and in vivo experiments including growth trials on 2,4-bis (trichloromethyl)-benzo [1, 3]dioxin-6-carboxylic acid

The British Journal of Nutrition
A DaviesF T Boyle

Abstract

1. A procedure for measuring methane production by rumen contents incubated anaerobically in vitro is described. Assessments of methane production in vivo, in both sheep and cattle, were made by withdrawal of rumen contents and measuring their capacity to produce methane in vitro. 2. Many members of a series of 6-substituted 2,4-bis (trichloromethyl)-benzo[1,3]dioxins were potent inhibitors of methanogenesis by rumen contents in vitro. The most potent compound inhibited methane production by 70% or more at a concentration of 1 microgram/ml (approximately 2.5 mumol/l). 3. Two compounds, namely the 6-carboxylic acid (ICI 13409) and the 6-carboxamide (ICI 43586), caused a large inhibition of methanogenesis sustained for many hours, following a single intrarumen injection in sheep or cattle. Inhibition was maintained for long periods by single daily dosing directly into the rumen or by dietary administration. 4. In a 28-week growth trial in beef cattle inclusion of ICI 13409 in the concentrate element of the diet, at a level of 6 mg/kg body-weight, improved live-weight gain by 8.0% (P less than 0.05) with respect to untreated animals whilst reducing food intake by 5.0% (P less than 0.05). Smaller and not statistically-significant e...Continue Reading

References

Nov 1, 1975·The British Journal of Nutrition·J W Czerkawski, G Breckenridge
Apr 1, 1974·Journal of Animal Science·M S SawyerC J Sniffen
Dec 3, 1971·Nature·B C McBride, R S Wolfe
Mar 1, 1972·Journal of Animal Science·J E TreiR C Parish
Apr 1, 1971·Journal of Dairy Science·J E TreiY K Singh

Citations

Nov 1, 1987·The British Journal of Nutrition·M Wakita, S Hoshino
Feb 1, 1986·Archiv für Tierernährung·D DemeyerJ M Godeau
Oct 11, 2003·Journal of Environmental Quality·Luis Orlindo TedeschiThomas Paul Tylutki
Jan 1, 1994·Archiv für Tierernährung·J P Jouany
Sep 1, 1996·Environmental Monitoring and Assessment·C Van Nevel, D Demeyer
May 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Stephen W Ragsdale
Mar 21, 2007·Journal of Dairy Science·N E OdongoBrian W McBride
Jul 5, 2018·Frontiers in Veterinary Science·Emilio M Ungerfeld

Related Concepts

ICI 13409
Bos indicus
Diet
Dioxins
Methane
Rumensin
Rumen
Dall Sheep

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