Properties of a subpopulation of T cells bearing histamine receptors

The Journal of Clinical Investigation
M PlautC S Henney

Abstract

C57BL/6 mice immunized i.p. with alloantigen (P815 mastocytoma cells) develop cytolytically active thymus-derived (T) splenic lymphocytes. The definition of specific histamine receptor sites on effector T cells has been studied by measuring the in vitro effects of the hormone on cytolytic activity. Histamine was found to inhibit cytolysis reversibly and to increase lymphoid cell cyclic AMP levels. Both of these histamine activities were reversed by burimamide and metiamide; neither activity was affected by diphenhydramine or pyrilamine. These findings indicate that modulation of effector T cell activity by histamine is mediated only by one of the subtypes of tissue histamine receptors, designated a histamine-type 2 receptor. This receptor appears to be present on cytolytically active cells; there is no evidence for activation by histamine of auxiliary or "suppressor" cells. The estimated dissociation constant (KB) for the burimamide-receptor complex (9 times 10-minus 6 tm) and for the metiamide-receptor complex (8 times 10-minus 7 M) indicated that the histamine receptor on T cells is quite similar to histamine-type 2 receptors in other tissues. Cells bearing such receptors could not be isolated by passage through a column of h...Continue Reading

References

Jan 1, 1971·Transplantation Reviews·J Klein, D C Shreffler
Apr 5, 1974·Science·H R BourneG M Shearer
Jan 1, 1973·Transplantation Reviews·C S Henney
Dec 1, 1973·European Journal of Immunology·A H Greenberg
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·U KrugP Cuatrecasas
Jan 1, 1974·The Journal of Clinical Investigation·K L MelmonS Bauminger
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Apr 21, 1972·Nature·J W BlackE M Parsons
Jul 1, 1972·The Journal of Experimental Medicine·R K Gershon, S A Liebhaber
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J PatrickJ H Steinbach
Nov 1, 1972·The Journal of Experimental Medicine·G M ShearerM Sela
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jun 1, 1972·The Journal of Experimental Medicine·K ShortmanJ C Cerottini
Dec 1, 1973·Cellular Immunology·R D Stulting, G Berke
Feb 1, 1969·Transplantation·T C Moore, R W Schayer
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

❮ Previous
Next ❯

Citations

Jan 1, 1987·Veterinary Research Communications·G A AndersonB I Osburn
Jan 1, 1982·Archives of Dermatological Research·K Thestrup-PedersenH Zachariae
Jun 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·V A Tomilets
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F PatroneC Sacchetti
Jan 1, 1981·Springer Seminars in Immunopathology·D Y Leung, R S Geha
Dec 1, 1982·Agents and Actions·M R Vickers, K J Sykes
Apr 1, 1981·Cellular Immunology·Y ThomasD Granjon
Jun 1, 1989·Cellular Immunology·M M KhanA M Krensky
May 16, 1980·European Journal of Pharmacology·S Seo, K Saeki
Jan 21, 1988·Journal of Immunological Methods·J MaebaF Paraskevas
Nov 1, 1980·The Journal of Allergy and Clinical Immunology·N A Soter, S I Wasserman
Apr 1, 1980·Immunopharmacology·R D Peterson, G C Palmer
Jun 1, 1980·Immunopharmacology·A SchwartzR K Gershon
Aug 1, 1986·Immunopharmacology·K TasakaM Kakimoto
Jan 1, 1985·International Journal of Immunopharmacology·N K Nanda, I Nath
Jan 10, 1981·Lancet·P J HowanitzH V Lamberson
Jan 10, 1981·Lancet·S E Presser, H Blank
Aug 6, 1983·Lancet·K LaffertyL T Cotton
Jan 15, 1981·The New England Journal of Medicine·M E OsbandR Parkman
Dec 1, 1975·The Journal of Experimental Medicine·R A ClarkA P Kaplan
Jun 1, 1976·Scandinavian Journal of Immunology·W P ZeijlemakerV P Eijsvoogel
Oct 1, 1979·International Journal of Dermatology·T F Downham, L B Savoy
Sep 1, 1994·Allergy·T B BuryM F Radermecker
Jul 1, 1979·British Journal of Pharmacology·J L Beets, M M Dale
Oct 1, 1990·Annals of the Rheumatic Diseases·J E NaschitzJ H Boss
Mar 1, 1989·Journal of Neuroimmunology·A MillerN Lahat
May 1, 1982·The American Journal of the Medical Sciences·G DelpreE Livni
Oct 1, 1980·The Journal of Allergy and Clinical Immunology·M M Frank
Sep 15, 1979·Lancet·B RotoliF Alfinito

❮ Previous
Next ❯

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