Cytophilic activity for macrophages was shown to be a property possessed by most, if not all, of the complement binding 7S gamma(2)-population of guinea pig antibodies. Cytophilic antibodies were also demonstrated in rabbit and mouse antisera to sheep red cells. While each species antibody best sensitized homologous macrophages, cross species sensitization was also observed. The binding site for macrophages resides on the Fc fragment, therefore, on the H chains, and is destroyed by pepsin hydrolysis or reduction and alkylation. The binding reaction is reversible with a high rate of dissociation at 37 degrees C. Cytophilic activity is not complement dependent, and was shown to be that property of opsonizing antibody which provides the receptors that permit the binding of the antibody to the macrophage cell membrane in preparation for phagocytosis.
Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis
Properties of guinea pig 7S antibodies. I. Electrophoretic separation of two types of guinea pig 7S antibodies
Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis
INFLUENCE OF MERCAPTOETHANOL TREATMENT ON SKIN SENSITIZING AND COMPLEMENT BINDING ABILITY OF 7 S ANTI-DINITROPHENOL-BOVINE GAMMA GLOBULIN ANTIBODY
ELECTROPHORETIC SEPARATION AND PROPERTIES OF MOUSE ANTIHAPTEN ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS ANAPHYLAXIS AND PASSIVE HEMOLYSIS
IN VITRO STUDIES OF CELLULAR HYPERSENSITIVITY. II. RELATIONSHIP OF DELAYED HYPERSENSITIVITY AND INHIBITION OF CELL MIGRATION BY PICRYLATED PROTEINS
Fine structural analysis of rabbit synovial cells. II. Fine structure and rosette-forming cells of explant and monolayer cultures
Participation of cytophilic antibody in enhancement of interferon production in macrophages by under-neutralized NDV
Eosinophi-mediated destruction of Schistosoma mansoni eggs in vitro. II. The role of cytophilic antibody
Further studies on the adsorption of antibody by guinea pig lung and the subsequent fixation of antigen
Further comparison of guinea pig gamma-1-and gamma-2-immunoglobulins. Amino acid compositions of the polypeptide chains and papain fragments
Inhibition of lymphoma cell proliferation by supernatant from fibrosarcoma cultures: preliminary evidence that the inhibitory material is prostaglandin E
Regulation of human natural cytotoxicity by IgG--I. Characterization of the structural site on monomeric IgG responsible for inhibiting natural killer cell activity
The interaction of particulate horseradish peroxidase (HRP)-anti HRP immune complexes with mouse peritoneal macrophages in vitro
Phagocytosis in subacute bacterial endocarditis. Localization of the primary opsonic site to Fc fragment
A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization
Immunodeviation by passive antibody, an expression of selective immunodepression. II. Action of guinea pig IgG1 and IgG2 anticarrier antibodies
Effects of serum on membrane transport. I. Separation and preliminary characterization of factors which depress lysine or stimulate adenosine transport in rabbit alveolar macrophages
Critical role of determinant presentation in the induction of specific responses in immunocompetent lymphocytes
Macrophage-lymphocyte interaction. I. Characteristics of the antigen-independent-binding of guinea pig thymocytes and lymphocytes to syngeneic macrophages
Characterization of the macrophage receptro for complement and demonstration of its functional independence from the receptor for the Fc portion of immunoglobulin G
Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation
Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane
Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes
2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory effect
Augmentation of macrophage complement receptor function in vitro. I. Characterization of the cellular interactions required for the generation of a T-lymphocyte product that enhances macrophage complement receptor function
Host defense mechanisms against infection with influenza virus. I. Effect of sensitized spleen cells on infection in vitro
FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA
Receptor sites on human monocytes for complement: binding of red cells sensitized by cold autoantibodies
Mechanisms of red cell destruction mediated by non-complement binding IgG antibodies: the essential role in vivo of the Fc part of IgG
Specificity of Fc-receptors on lymphocytes and monocytes for guinea-pig IgG1 and IgG2: phagocytosis of erythrocytes
Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells
Modification of antityphus antibodies on passage through the gut of the human body louse with discussion of some epidemiologic and evolutionary implications
Characterizaiton of two populations of human lymphocytes bearing easily detectable surface immunoglobulin
Human alveolar macrophage cytophilic immunoglobulin G-mediated phagocytosis of protein A-positive staphylococci
Scintigraphic distribution of complexes of antiinsulin antibodies and 123I-insulin. In vivo studies in rats
Detection of macrophage receptors for heterologous IgG by scanning and transmission electron microscopy
Macrophage-Fc-receptor affinity: role in cellular mediation of antibody initiated glomerulonephritis
Opsonic activity of ascitic fluids from Plasmodium falciparum-infected Saimiri monkey: positive correlation with protection in passive transfer assay
A comparative study of the effect of modification of the surface of human platelets on the receptors for aggregated immunoglobulins and for ristocentin-von Willebrand factor
Suppression and augmentation of the primary in vitro immune response by different classes of antibodies
Opsonizing effect of serum and albumin gland extracts on the elimination of human erythrocytes from the circulation of Helix pomatia
The association of suppressor cells with mononuclear cell aggregates in spleens of tumor-bearing mice
Uptake of aldehyde-treated erythrocytes by L2 cells: inhibition by anti-red cell antibody or by coating the erythrocytes with purified proteins
Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages
Rosette-forming cells in the unimmunized mouse: morphological studies with phase contrast and electron microscopy
Antigen binding to lymphoid cells from unimmunized mice: high frequency of beta-galactosidase binding cells at optimal conditions
The destruction of allogeneic tumour cells by antibody and adherent cells from peritoneal cavities of mice
Expression and modulation of virus receptors on lymphoid and myeloid cells: relationship to infectivity
Effect of concanavalin A and its succinylated derivative on the oxidative metabolism of guinea pig peritoneal macrophages
IgG-binding sites on macrophage cell membrane. I. Identification of two distinct Fc receptors on mouse peritoneal macrophages
Isolation and characterisation of mononuclear phagocytes from the bone marrow, blood, and peritoneal cavity of the guinea-pig
Langerhans cells: role in contact hypersensitivity and relationship to lymphoid dendritic cells and to macrophages
Gene expression of the constant region of the heavy chain of immunoglobulin G (IgG CRHC) is down-regulated in human decidua in association with preeclampsia
Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells
Binding of monomeric immunoglobulins by bone marrow-derived mononuclear phagocytes; its modulation by interferon-gamma
Linear alignment of the cyanogen bromide fragments of heavy chain from strain 13 guinea pig immunoglobulin G2
The lethal hit stage of mouse T and non-T cell-mediated cytolysis: differences in cation requirements and characterization of an analytical "cation pulse" method
Interaction between IgE complexes and macrophages in the rat: a new mechanism of macrophage activation
Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype
Studies on release of modified cytophilic antibodies from the surface of macrophages in the presence of antigens
Synthetic antigens. II. Immunogenic, antigenic and adjuvant properties of a copolymer of styrene and maleic anhydride
Phagocytosis requires repeated triggering of macrophage phagocytic receptors during particle ingestion
Electron microscopic studies of human monocyte and lymphocyte interaction with immunoglobulin- and complement-coated erythrocytes
Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules
Quantitative proteome analysis of temporally resolved phagosomes following uptake via key phagocytic receptors.
Control of normal differentiation of myeloid leukemic cells. XII. Isolation of normal myeloid colony-forming cells from bone marrow and the sequence of differentiation to mature granulocytes in normal and D+ myeloid leukemic cells
Reprogramming the Constant Region of Immunoglobulin G Subclasses for Enhanced Therapeutic Potency against Cancer.
Anaphylactic augmentation by epicutaneous sensitization to acid-hydrolyzed wheat protein in a guinea pig model
Immunoglobulin receptors on mouse mast cells. 3. Inhibition of rosette formation of mastocytomas and antibody-coated erythrocytes by myeloma and antibody immunoglobulins, free or bound to antigen
Relationship between immunity and interferon production in macrophages. 3. Enhancement of interferon production by antiserum
Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex
Destruction of dextran-coated target cells by normal human lymphocytes and monocytes. Induction by a human anti-dextran serum with IgG antibodies restricted to the IgG2 subclass
Pathopysiological aspects of immune complex diseases. Part II. Phagocytosis, exocytosis, and pathogenic depositions
Sudan ebolavirus long recovered survivors produce GP-specific Abs that are of the IgG1 subclass and preferentially bind FcγRI
Ultrastructural studies of leucocytes which form rosettes with homologous erythrocytes in human auto immune haemolytic anaemia
Receptors for immune complexes on bovine peripheral blood lymphocytes. 1. Fc receptors: enzymatic behaviour, dissociation and regeneration
Delayed hypersensitivity, macrophage migration, and antibodies in guinea-pigs immunized with diphtheria toxoid. II. Macrophage cytophilic antibody to diphtheria toxoid in desensitized animals
Implications of receptors for the Fc portion of IgG (FcgammaRs) in mechanism of action of therapeutic antibodies
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