PMID: 1081576Nov 1, 1975Paper

Properties of antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. I. In vivo activity and immunochemical characterization

The Journal of Experimental Medicine
T Takemori, T Tada

Abstract

An antigen-specific suppressive T-cell factor was extracted from physically disrupted thymocytes and spleen cells of mice that had been immunized with soluble protein antigens. The factor, when inoculated into syngeneic normal mice, could induce a significant suppression of IgG antibody response against a hapten coupled to the carrier protein by which the donor of the suppressor factor was immunized. The suppressor factor was found only effective in suppressing the antibody response of syngeneic or H-2 histocompatible recipients. The suppressive T-cell factor was removed by absorption with immunoadsorbent composed of the relevant antigen, but not with any of those of anti-immunoglobulin antibodies. The factor was successfully removed by alloantibodies with specificity for the K end (H-2K, I-A and I-B) of the H-2 complex of the donor strain, but not by those for the D end (I-C, SsSlp, and H-2D). The activity was removed by absorption with a heterologous antithymocyte serum. The mol wt of the suppression T-cell factor was between 35,000 and 60,000 as determined by Sephadex G-200 gel filtration. The suppressive T-cell factor was found to be a heat-liable protein.

References

Mar 1, 1975·The Journal of Experimental Medicine·D C Benjamin
Dec 1, 1974·The Journal of Experimental Medicine·D ArmerdingD H Katz
May 3, 1972·Nature: New Biology·A Schimpl, E Wecker
Jul 1, 1974·The Journal of Experimental Medicine·A BastenC Cheers
Mar 15, 1974·Nature·M J Taussig

Citations

Dec 1, 1980·Immunology·M J Taussig
Dec 22, 1978·Molecular and Cellular Biochemistry·H Binz, H Wigzell
Jan 1, 1991·Journal of Clinical Immunology·M T Halpern
Dec 18, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Varuna R AluvihareAlexander G Betz
Jan 1, 1980·Journal of Immunological Methods·A Altman, D H Katz
Jan 1, 1989·Developmental and Comparative Immunology·H KoshimoN Yamaguchi
Jul 1, 1980·Molecular Immunology·J W GoodmanN H Ruddle
Jun 1, 1980·Immunopharmacology·R S Krakauer, J D Clough
Jun 1, 1982·Veterinary Parasitology·L C Gasbarre, J F Urban
Oct 1, 1996·Cytokine & Growth Factor Reviews·G F Weber, H Cantor
Aug 3, 1978·Nature·S KontiainenM Feldmann
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B D SchwartzR H Schwartz
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F L OwenA Nisonoff
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S A SchwartzY S Choi
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S MiyataniT Tada
Aug 1, 1976·The Journal of Experimental Medicine·P J Durda, P D Gottlieb
Mar 1, 1977·The Journal of Experimental Medicine·J S McDougal, D S Gordon
Apr 1, 1977·The Journal of Experimental Medicine·I F McKenzieC R Parish
Aug 1, 1977·The Journal of Experimental Medicine·D H SachsJ K Lunney
Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Feb 1, 1982·The Journal of Experimental Medicine·A F Clark, J D Capra
Jan 1, 1976·Scandinavian Journal of Immunology·R H SchwartzB D Schwartz
Jan 1, 1976·Scandinavian Journal of Immunology·J T KurnickH M Grey
Jan 1, 1978·Scandinavian Journal of Immunology·R H Schwartz
Jan 1, 1976·Transplantation Reviews·B D SchwartzE M Shevach
Jan 1, 1976·Transplantation Reviews·S E CullenS G Nathenson
Jan 1, 1976·Transplantation Reviews·C S David
Jan 1, 1979·Immunological Reviews·R E BallieuxB J Zegers
Jan 1, 1976·Immunological Communications·T TadaT Takemori
Jan 1, 1975·Transplantation Reviews·T TadaT Takemori
Jan 1, 1979·Annals of the New York Academy of Sciences·A EisenthalM Feldman
Oct 1, 1984·Scandinavian Journal of Immunology·M ZöllerG Andrighetto
Jan 1, 1983·Annals of the New York Academy of Sciences·M McNamaraH Kohler
Jan 1, 1981·Scandinavian Journal of Immunology·B Benacerraf, R N Germain
Dec 1, 1988·Scandinavian Journal of Immunology·R Z DintzisH M Dintzis
Apr 1, 1985·Immunological Reviews·M Taniguchi, T Sumida
Aug 1, 1978·Cellular Immunology·D E Singer, R M Williams
Dec 1, 1991·Immunology Today·Geoffrey Hoffmann
Jun 13, 1975·Annals of the New York Academy of Sciences·C W PierceT Tadakuma
May 1, 1980·Springer Seminars in Immunopathology·R N Germain, B Benacerraf
Aug 1, 1976·European Journal of Immunology·G J Hammerling, K Eichmann
May 1, 1983·Journal of Surgical Oncology·S SajiK Sakata
Jul 7, 2017·Interactive Journal of Medical Research·Reginald Gorczynski, Geoffrey Hoffmann
Oct 1, 1977·European Journal of Immunology·C Bell, H Wigzell
May 1, 1977·European Journal of Immunology·S Kontianinen, M Feldmann

Related Concepts

Antibody Formation
Antigens
Carrier Proteins
Cell Fractionation
Cell-Free System
Molecular Sieve Chromatography
Haptens
Hemocyanin
Histocompatibility
Polyglobin

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