PMID: 375379Jan 1, 1979Paper

Properties of antinuclear antibodies that cross-react with plasma membranes

Scandinavian Journal of Immunology
O P Rekvig, K Hannestad

Abstract

Certain human antinuclear antibodies (ANA) cross-react specifically with the surface membrane of human leucocytes. In the present work these cross-reacting (X) ANA could be eluted directly from viable leucocytes isolated from three patients. The plasma membrane antigen recognized by X-ANA appeared phylogenetically highly conserved since it was present on viable HeLa cells and cells from mouse and rabbit spleen, rat liver, and the slime mould Physarum polycephalum. X-ANA did not react with the plasma membrane of nucleated bird erythrocytes or human erythrocytes or thrombocytes. The same X-ANA subset reacted with the various cells. The presence of X-ANA correlated strongly (P less than 0.01) with antibodies against a HeLa cell surface antigen. The nuclear antigen recognized by X-ANA was present in all species examined, including bird erythrocyte nuclei and nuclei of Physarum polycephalum. Native or denatured DNA, RNA or a saline extract of nuclei did not inhibit the binding of X-ANA to cell nuclei.

References

Jan 1, 1977·Vox Sanguinis·O P Rekvig, K Hannestad
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E M JohnsonH R Matthews
Jan 1, 1978·Scandinavian Journal of Immunology·K Hannestad
Oct 19, 1978·Nature·K Hannestad, B D Stollar
Jan 1, 1976·Scandinavian Journal of Immunology·K Hannestad, A Johannessen
Jan 1, 1975·Annual Review of Biochemistry·S C Elgin, H Weintraub

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Citations

Jan 1, 1981·Springer Seminars in Immunopathology·K HannestadA Husebekk
Oct 1, 1990·Hybridoma·J M Sorace, R J Johnson
Sep 1, 1985·The Journal of Clinical Investigation·V M Holers, B L Kotzin
Jan 1, 1981·Scandinavian Journal of Immunology·O P Rekvig, K Hannestad
Feb 1, 1984·Annals of Tropical Medicine and Parasitology·C Daniel RibeiroM Gentilini

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