Properties of Ca(2+) release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres

British Journal of Pharmacology
T Ikemoto, M Endo

Abstract

1. To characterize the effect of clofibric acid (Clof) on the Ca(2+) release mechanism in the sarcoplasmic reticulum (SR) of skeletal muscle, we analysed the properties of Clof-induced Ca(2+) release under various conditions using chemically skinned skeletal muscle fibres of the mouse. 2. Clof (>0.5 mM) released Ca(2+) from the SR under Ca(2+)-free conditions buffered with 10 mM EGTA (pCa >8). 3. Co-application of ryanodine and Clof at pCa >8 but not ryanodine alone reduced the Ca(2+) uptake capacity of the SR. Thus, Ca(2+) release induced by Clof at pCa >8 must be a result of the activation of the ryanodine receptor (RyR). 4. At pCa >8, (i) Clof-induced Ca(2+) release was inhibited by adenosine monophosphate (AMP), (ii) the inhibitory effect of Mg(2+) on the Clof-induced Ca(2+) release was saturated at about 1 mM, and (iii) Clof-induced Ca(2+) release was not inhibited by procaine (10 mM). These results indicate that Clof may activate the RyR-Ca(2+) release channels in a manner different from Ca(2+)-induced Ca(2+) release (CICR). 5. In addition to this unique mode of opening, Clof also enhanced the CICR mode of opening of RyR-Ca(2+) release channels. 6. Apart from CICR, a high concentration of Ca(2+) might also enhance the uni...Continue Reading

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Citations

May 5, 2004·Best Practice & Research. Clinical Rheumatology·Sandrine GuisFrédéric Lioté
Jun 18, 2003·Current Opinion in Pharmacology·Eric P HoffmanRichard R Almon
Oct 21, 2005·Life Sciences·Sumio MatznoKenji Matsuyama
Jan 1, 2010·Atherosclerosis·Abhijit GhatakPaul D Thompson
Jun 15, 2007·Toxicologic Pathology·Miyoko OkadaShiro Takagi
Dec 4, 2003·Journal of Pharmacological Sciences·Ryotaku InoueMakoto Endo
Jul 29, 2009·Nature Reviews. Endocrinology·Terry A Jacobson
Oct 1, 2009·Physiological Reviews·Makoto Endo
Feb 9, 2012·The Journal of Physiology·Lourdes FigueroaEduardo Ríos
Jul 5, 2003·The Journal of Pharmacy and Pharmacology·Sumio MatznoKenji Matsuyama

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