Properties of carbon nanotube-dispersed Sr-hydroxyapatite injectable material for bone defects

Regenerative Biomaterials
M G RaucciL Ambrosio

Abstract

This study concerns the synthesis of gel materials based on carbon nanotubes dispersed strontium-modified hydroxyapatite (Sr-HA) at different compositions obtained by sol-gel technology and their influence on human-bone-marrow-derived mesenchymal stem cells. Furthermore, an evaluation of the influence of nanotubes and Strontium on physico-chemical, morphological, rheological and biological properties of hydroxyapatite gel was also performed. Morphological analysis (scanning electron microscopy) shows a homogeneous distribution of modified nanotubes in the ceramic matrix improving the bioactive properties of materials. The biological investigations proved that Sr-HA/carbon nanotube gel containing 0-20 mol (%) of Sr showed no toxic effect and promote the expression of early and late markers of osteogenic differentiation in cell culture performed in basal medium without osteogenic factors. Finally, the SrHA/carbon nanotube gels could have a good potential application as filler in bone repair and regeneration and may be used in the osteoporotic disease treatment.

References

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Citations

Jan 9, 2018·Royal Society Open Science·Muhammad Anwaar NazeerIskender Yilgor
Sep 13, 2018·Journal of Biomedical Materials Research. Part a·Ugo D'AmoraLuigi Ambrosio
Jun 3, 2020·Advanced Healthcare Materials·Maria Grazia RaucciLuigi Ambrosio
Sep 12, 2018·Current Osteoporosis Reports·Jancineide Oliveira de CarvalhoAnderson Oliveira Lobo
Jun 3, 2021·International Journal of Molecular Sciences·Li-Ching ChangJen-Tsung Yang
Nov 21, 2018·ACS Applied Materials & Interfaces·Maria Grazia RaucciLuigi Ambrosio

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Methods Mentioned

BETA
Infrared Spectroscopy
transmission
scanning electron microscopy
Reverse Transcription Polymerase
electrophoresis
PCR

Software Mentioned

Gel

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