Properties of cerebellar fastigial neurons during translation, rotation, and eye movements

Journal of Neurophysiology
Aasef G ShaikhDora E Angelaki

Abstract

The most medial of the deep cerebellar nuclei, the fastigial nucleus (FN), receives sensory vestibular information and direct inhibition from the cerebellar vermis. We investigated the signal processing in the primate FN by recording single-unit activities during translational motion, rotational motion, and eye movements. Firing rate modulation during horizontal plane translation in the absence of eye movements was observed in all non-eye-movement-sensitive cells and 26% of the pursuit eye-movement-sensitive neurons in the caudal FN. Many non-eye-movement-sensitive cells recorded in the rostral FN of three fascicularis monkeys exhibited convergence of signals from both the otolith organs and the semicircular canals. At low frequencies of translation, the majority of these rostral FN cells changed their firing rates in phase with head velocity rather than linear acceleration. As frequency increased, FN vestibular neurons exhibited a wide range of response dynamics with most cells being characterized by increasing phase leads as a function of frequency. Unlike cells in the vestibular nuclei, none of the rostral FN cells responded to rotational motion alone, without simultaneously exhibiting sensitivity to translational motion. Mo...Continue Reading

References

Jan 1, 1992·Annual Review of Neuroscience·W T ThachJ G Keating
Nov 1, 1991·IEEE Transactions on Bio-medical Engineering·D E Angelaki
Jun 1, 1991·Journal of Neurophysiology·U BüttnerP Buckmaster
Dec 1, 1990·Brain Research Bulletin·A Gonzalo-Ruiz, G R Leichnetz
Jan 1, 1981·Experimental Brain Research·D L TomkoR H Schor
Jan 1, 1993·Biological cybernetics·D E Angelaki
Jan 7, 1998·Experimental Brain Research·X SiJ D Dickman
Feb 24, 2001·Experimental Brain Research·C SieboldU Büttner
Aug 3, 2001·Experimental Brain Research·W ZhouW M King
Dec 6, 2002·Journal of Neurophysiology·J David Dickman, Dora E Angelaki
Oct 1, 1963·IEEE Transactions on Bio-medical Engineering·D A ROBINSON
Sep 30, 2003·The Journal of Comparative Neurology·Shawn D NewlandsAdrian A Perachio
Apr 2, 2004·Journal of Neurophysiology·Andrea M Green, Dora E Angelaki

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Citations

Mar 14, 2009·Experimental Brain Research·Soroush G SadeghiKathleen E Cullen
Dec 17, 2009·The Cerebellum·Dora E AngelakiPablo M Blazquez
Nov 28, 2012·Nature Neuroscience·Sheng LiuDora E Angelaki
Dec 17, 2008·Journal of Neurophysiology·Ayanna S Bryan, Dora E Angelaki
Jul 16, 2010·Journal of Neurophysiology·Christopher R FetschGregory C Deangelis
Sep 25, 2009·BMC Neuroscience·Jorge M SerradorScott J Wood
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul R MacNeilageDora E Angelaki
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheng Liu, Dora E Angelaki
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica X Brooks, Kathleen E Cullen
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tatyana YakushevaDora E Angelaki
Jan 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheng LiuDora E Angelaki
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hongge LuanGreg T Gdowski
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aihua ChenDora E Angelaki
Mar 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aihua ChenDora E Angelaki
Oct 1, 2013·Nature Neuroscience·Jean LaurensDora E Angelaki
Aug 4, 2015·Nature Neuroscience·Jessica X BrooksKathleen E Cullen
Jul 11, 2014·Frontiers in Behavioral Neuroscience·Enrica L Santarcangelo
Feb 27, 2007·Vision Research·Jing TianMark F Walker
Jun 7, 2008·Experimental Brain Research·Vladimir Marlinski, Robert A McCrea
Sep 18, 2010·Experimental Brain Research·E L SantarcangeloD Manzoni
Sep 2, 2005·Journal of Neural Engineering·Andrea M GreenDora E Angelaki
Sep 1, 2006·Journal of Neurophysiology·Wu ZhouW M King
Mar 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong ChenDora E Angelaki
May 15, 2009·Journal of Neurophysiology·Julie Quinet, Laurent Goffart
Jun 28, 2018·Frontiers in Neurology·Aasef G ShaikhFatema F Ghasia
Dec 14, 2018·The Cerebellum·Sherry Y Tang, Aasef G Shaikh
Aug 4, 2009·Annals of the New York Academy of Sciences·Dora E Angelaki, Tatyana A Yakusheva
Oct 27, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Sinem Balta BeylergilAasef G Shaikh
May 19, 2021·Journal of Neurology·Sinem Balta BeylergilAasef G Shaikh
Sep 24, 2021·Journal of Neurology·Sinem Balta BeylergilAasef G Shaikh
Dec 1, 2009·Neuron·Dora E AngelakiLawrence H Snyder

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