PMID: 9178039Apr 1, 1997Paper

Properties of developing lateral geniculate neurones in the mouse

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
N MacLeodJ Edgar

Abstract

This study describes the properties of neurones recorded in vitro from the dorsal lateral geniculate nucleus (dLGN) of the mouse between developmental stages E16 and P36 and represents the first systematic study of the development of rodent thalamic neurones. The results demonstrate that thalamo-cortical neurones in the mouse dLGN undergo a series of important changes as they mature. Prenatally recorded cells had low resting potentials and could not generate action potentials but as they mature, mouse dLGN neurones become more polarised and show an increase in membrane time constant and spike threshold, while action potentials increase in amplitude and decrease in width. The low-threshold spike (LTS) complex appears at the time of birth, but does not show properties typical of adult cells until at least the third postnatal week. Immature action potentials are primarily sodium-dependent but gain a significant calcium component in the second postnatal week, which is associated with a supra-threshold oscillation of the membrane potential. The electrical activity during this critical period is strongly influenced by the interaction of powerful inward and outward rectification with calcium conductances which determines the appearanc...Continue Reading

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Citations

Aug 1, 2011·Biomolecular Concepts·Rajiv Wijesinghe, Aaron J Camp
Apr 12, 2018·Journal of Neurophysiology·William Guido
Nov 12, 2013·Developmental Neurobiology·Yamini Venkataraman, Edward L Bartlett
Jun 27, 2014·Journal of Neurophysiology·Jessica L HauserChinfei Chen
Oct 3, 2017·Visual Neuroscience·Elizabeth Y Litvina, Chinfei Chen
May 25, 2021·Frontiers in Neuroinformatics·Ruben A Tikidji-Hamburyan, Matthew T Colonnese
Jul 23, 2021·Neuron·Francisco J MartiniGuillermina López-Bendito

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