PMID: 40400Jun 1, 1979

Properties of erythrocyte catalase from heterozygotes for Japanese type acatalasemia

Acta Medica Okayama
M Ogata, J Mizugaki

Abstract

The level of blood catalase activity in heterozygotes for Japanese type acatalasemia was demonstrated to be about half of normal levels by means of titration and spectrophotometric methods. A distribution plot of catalase activities in heterozygous blood was completely separate from that of normal blood. Comparative analysis of the partially purified erythrocyte catalase preparations obtained from normal and heterozygous individuals revealed no distinct differences between them regarding stability to heat, sodium dodecyl sulfate and some enzyme inhibitors or pH dependency. The erythrocyte catalase in heterozygotes for Japanese type acatalasemia contains about half the normal specific activity and as stable as that in normal individuals.

Related Concepts

Acatalasemia Swiss Type
Enzyme Inhibitor Drugs
Acatalasia
Sodium Dodecyl Sulfate
Catalase T
Enzyme Inhibitors
Titration Method
Erythrocytes
Enzyme Inhibitors [MoA]
CAT

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