Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells

European Journal of Pharmacology
Kenzo KudoE Takahashi

Abstract

To investigate the relationship between the inhibitory effects of ginseng saponins (ginsenosides) on acetylcholine-evoked secretion of catecholamines and the structures of ginsenosides, we examined the effects of ginsenoside-Rg3 and -Rh2, which are panaxadiol saponins, 20(R)- and 20(S)-ginsenoside-Rg2, which are epimers involving the hydroxyl group at C-20 of sapogenin, and other plant saponins on the acetylcholine-evoked secretion of catecholamines from cultured bovine adrenal chromaffin cells. The ginsenoside-Rg3 (1-100 microM) and -Rh2 (10-100 microM) greatly reduced the acetylcholine-evoked secretion in a concentration-dependent manner comparable to that of ginsenoside-Rg2, a panaxatriol saponin, which was the most potent inhibitor in our previous study. 20(R)- and 20(S)-ginsenoside-Rg2 (1-100 microM) similarly reduced the acetylcholine-evoked secretion. In contrast, saikosaponin-a, glycyrrhizin and the cardiac glycosides (100 nM-100 microM), digitoxin and digoxin, had no significant inhibitory effect on catecholamine secretion. Saikosaponin-c (10-100 microM), however, had an inhibitory effect, which was less than that of ginsenoside-Rg2 and -Rg3. These results strongly suggest that the inhibitory effects of ginsenosides on...Continue Reading

References

Apr 1, 1977·Journal of Neurochemistry·S P Wilson, N Kirshner
Aug 1, 1977·Japanese Journal of Pharmacology·H SaitoK Takagi
Jun 10, 1988·European Journal of Pharmacology·H YoshimuraN Ogawa
Oct 1, 1952·The Journal of Mental Science·H WEIL-MALHERBE
Mar 1, 1982·Planta medica·B H HanO Tanaka

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Jul 27, 2005·Archives of Pharmacal Research·Jong-Hoon KimSeung-Yeol Nah
Feb 6, 2003·Archives of Pharmacal Research·Se-Eun ChoiSeung-Yeol Nah
Aug 17, 2011·Applied Biochemistry and Biotechnology·Bong-Gwan KimHyung Joo Suh
Apr 16, 1999·European Journal of Pharmacology·E TachikawaE Takahashi
Jan 5, 2008·Photochemistry and Photobiology·Omer Yalinkilic, Huseyin Enginar
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Jong-Hoon KimSeung-Yeol Nah
Jan 9, 2010·Bioscience, Biotechnology, and Biochemistry·Lei LiuChang-Keun Sung
Jun 23, 2005·Journal of Ethnopharmacology·Zahoor Ahmad ShahShashi Bharat Vohora
Nov 26, 1999·Biochemical Pharmacology·A S AtteleC S Yuan
Oct 26, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hanumantha Rao Balaji RaghavendranChang-Gue Son
Oct 30, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyo-Jeong LimDong-Yoon Lim
Aug 9, 2005·Biotechnology Letters·Hyun Chi, Geun-Eog Ji
Jul 15, 2005·Molecular Pharmacology·Jun-Ho LeeSeung-Yeol Nah
Mar 30, 2018·Frontiers in Pharmacology·Ming PengJian Le
Mar 1, 2009·Mycobiology·Jong-Jin LeeJong-Lae Kim
Nov 17, 2016·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seung-Yeol NaDong-Yoon Lim
Nov 12, 2003·Biochemical Pharmacology·Eiichi TachikawaJon M Lindstrom

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