Sep 14, 1976

Properties of guanylate cyclase in adult rat liver and several Morris hepatomas

Biochimica Et Biophysica Acta
W E CrissH P Morris


Guanylate cyclase (GTP pyrophyosphate-lyase (cyclizing), EC activity was examined in preparations from normal rat liver and a series of Morris hepatomas. Homogenate gyanylate cyclase activites were 3.2, 1.6 and 1.2 nmol cyclic GMP formed per min/g tissue ihe non-substrate analogs of IMP were weak inhibitors of this enzyme, GMP and four of its analogs had Ki values ranging from 30 to 80 muM. The GMP analogs (8-azaGMP, 7-deaza-8-azaGMP, 2'-dGMP and beta-D-arabinosylGMP) and GMP were competitive inhibitors with respect to GTP.

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Mentioned in this Paper

Liver Carcinoma
Subcellular Fractions
Guanylate Cyclase
Liver Neoplasms, Experimental
Enzyme Activation

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