PMID: 7539058Feb 1, 1995Paper

Properties of networks controlling locomotion and significance of voltage dependency of NMDA channels: stimulation study of rhythm generation sustained by positive feedback

Journal of Neurophysiology
A RobertsE Wolf

Abstract

1. We have built a realistic 24-neuron model based on data from the spinal pattern generator for swimming in Xenopus embryos with the use of the SWIM programs. The neurons have dendrite, soma, and axon compartments with voltage-gated Na+ and K+ channels. Dendritic synapses were modeled as modulated ionic conductances with currents that have different reversal levels. One of these conductances was voltage dependent to model N-methyl-D-aspartate ("NMDA") synapses in the presence of Mg2+. 2. In this model, rhythm generation is initiated by a brief excitation, depends on rebound from reciprocal inhibition, and is sustained by long-duration "NMDA-dependent" feedback excitation. 3. Without NMDA voltage dependency, rhythmic activity is stable over a wide range of synaptic conductances. Its frequency decreases with more inhibition and increases with more excitation. The introduction of normally distributed variation in soma size or excitatory synaptic conductance extends the lower stable frequency range. Without such variation the frequency of the 24-neuron model is the same as a 4-neuron model provided that the synaptic conductances for each neuron are the same. 4. The effect of introducing NMDA voltage dependency on rebound after neg...Continue Reading

Citations

Mar 11, 2000·Journal of Neurophysiology·B Saint Mleux, L E Moore
Sep 5, 2014·Journal of Neurophysiology·G MartinoF Lacquaniti
Feb 3, 1999·Annals of the New York Academy of Sciences·A RobertsF Y Zhao
Feb 3, 1999·Annals of the New York Academy of Sciences·B J SchmidtJ N MacLean
Nov 15, 2006·The European Journal of Neuroscience·Nerijus Lamanauskas, Andrea Nistri
Feb 9, 2007·Journal of Neurophysiology·Mikael HussJeanette H Kotaleski
Oct 14, 2011·Journal of Neurophysiology·Tatiana M AndersonMark A Masino
Jul 3, 2003·Nature Reviews. Neuroscience·Sten Grillner
Jun 1, 1997·Journal of Neurophysiology·A ProchazkaD J Bennett
Dec 17, 2008·Journal of Neurophysiology·Allan J ThextonRebecca Z German
Apr 20, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·James D AngstadtSarah M Levasseur
Jul 31, 2003·The European Journal of Neuroscience·Simon P AikenNicholas Dale
Jul 4, 1998·Brain Research. Brain Research Reviews·S GrillnerP Wallén
Dec 1, 1995·Current Opinion in Neurobiology·R L Calabrese
Jan 1, 1995·Journal of Physiology, Paris·A Roberts, R Perrins
Feb 3, 1998·Progress in Neurobiology·N Dale, F M Kuenzi
Jul 3, 2021·International Journal of Molecular Sciences·Jessica AusbornSimon M Danner
Feb 12, 1998·Science·S Grillner

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