Properties of pellets manufactured by wet extrusion/spheronization process using kappa-carrageenan: effect of process parameters

AAPS PharmSciTech
Markus Thommes, Peter Kleinebudde

Abstract

The aim of this study was to systematically evaluate the pelletization process parameters of kappa-carrageenan-containing formulations. The study dealt with the effect of 4 process parameters--screw speed, number of die holes, friction plate speed, and spheronizer temperature--on the pellet properties of shape, size, size distribution, tensile strength, and drug release. These parameters were varied systematically in a 2(4) full factorial design. In addition, 4 drugs--phenacetin, chloramphenicol, dimenhydrinate, and lidocaine hydrochloride--were investigated under constant process conditions. The most spherical pellets were achieved in a high yield by using a large number of die holes and a high spheronizer speed. There was no relevant influence of the investigated process parameters on the size distribution, mechanical stability, and drug release. The poorly soluble drugs, phenacetin and chloramphenicol, resulted in pellets with adequate shape, size, and tensile strength and a fast drug release. The salts of dimenhydrinate and lidocaine affected pellet shape, mechanical stability, and the drug release properties using an aqueous solution of pH 3 as a granulation liquid. In the case of dimenhydrinate, this was attributed to the...Continue Reading

References

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Oct 1, 1995·Journal of Pharmaceutical Sciences·P Kleinebudde
Aug 15, 1998·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Schmidt, P Kleinebudde
Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Martin BornhöftPeter Kleinebudde
Oct 29, 2005·International Journal of Pharmaceutics·Matthew A HowardMarvin J Sack
Dec 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Markus Thommes, Peter Kleinebudde
Dec 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Markus Thommes, Peter Kleinebudde
Apr 24, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Markus ThommesPeter Kleinebudde

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Citations

Mar 15, 2012·AAPS PharmSciTech·Martin Koester, Markus Thommes
Mar 8, 2012·Nanomedicine·Steven J P McInnesNicolas H Voelcker
Mar 29, 2011·Drug Development and Industrial Pharmacy·Eva RobleggJohannes Khinast
Jul 27, 2012·Journal of Pharmaceutical Sciences·Katja Kristan, Matej Horvat
May 2, 2012·International Journal of Pharmaceutics·Martin KoesterMarkus Thommes
Nov 24, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G Di PretoroA Gazzaniga
Feb 22, 2011·International Journal of Pharmaceutics·Dima Ghanam, Peter Kleinebudde
Mar 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Markus ThommesPeter Kleinebudde
Feb 21, 2013·International Journal of Pharmaceutics·Shruti ChopraGuru V Betageri
Sep 6, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Dukić-OttC Vervaet
Jun 25, 2019·Pharmaceutical Development and Technology·Maria EversMarkus Thommes
May 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chang Joo LeePahn-Shick Chang
Nov 27, 2020·Marine Drugs·Edisson-Mauricio Pacheco-QuitoMaría-Dolores Veiga

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