PMID: 6972007May 14, 1981Paper

Properties of postsynaptic channels induced by acetylcholine in different frog muscle fibres

Nature
R Miledi, O D Uchitel

Abstract

Skeletal muscles in the frog are composed of two distinct classes of muscle fibre: fast muscle fibres capable of propagating action potentials and twitches, and slow muscle fibres normally unable to generate action potentials or twitches. In addition, amphibian muscles contain a spectrum of 'intermediate' fibres whose structural and functional properties lie between those of fast and slow fibres. Much is now known about the characteristics of the channels opened by the transmitter acetylcholine (ACh) acting on the membrane of fast fibres, but the molecular action of ACh on the other fibre types is only poorly understood. We report here the existence of a muscle in the mandibular arch of the frog in which most, if not all, the fibres are multiply innervated and are capable of eliciting action potentials. We also report that the channels induced by the transmitter on the synaptic membrane of fast, slow and submaxillaris muscle fibres differ in their lifetimes and conductances.

References

Jun 1, 1973·The Journal of Physiology·B Katz, R Miledi
Aug 1, 1972·The Journal of Physiology·B Katz, R Miledi
Sep 1, 1971·The Journal of Physiology·R MilediA B Steinbach
Dec 1, 1965·The Journal of Physiology·B Katz, R Miledi

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Citations

Jun 1, 1989·Pflügers Archiv : European journal of physiology·G ReiserR Miledi
Sep 1, 1982·Pflügers Archiv : European journal of physiology·V V FedorovA L Zefirov
Jan 1, 1984·Neir̆ofiziologiia = Neurophysiology·L G MagazanikV A Snetkov
Jan 1, 1983·Progress in Neurobiology·J J McArdle
Jan 1, 1987·Progress in Neurobiology·M L Mayer, G L Westbrook
Feb 15, 1983·Experientia·J A Macdonald
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A B Ribera, W L Nastuk
Jan 1, 1987·Journal of Neuroscience Research·O D Uchitel, R Miledi
Nov 17, 2015·Cell & Bioscience·Victor M LunaFumihito Ono
Jun 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F RuzzierR Miledi
May 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V Verma
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·J Kienlen

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