PMID: 9537030Jan 1, 1980Paper

Properties of purified papain-solubilized rat AgB antigens and reactivity of a xenoantiserum against the isolated antigens

Scandinavian Journal of Immunology
S KvistP A Peterson

Abstract

Rat AgB transplantation antigens were isolated after papain digestion of spleens from the inbred strain Hooded Lister. Both subunits of the AgB antigens were present in the purified material. Some physical characteristics of the antigens have been determined. An antiserum, raised in a rabbit, against the purified material reacted exclusively with AgB antigens on splenocytes but detected novel structures on both adult and embryonic fibroblasts. These structures, antigenically related to AgB antigens, were not detected on plasmacytoma or hepatoma cells, nor did they display any antigenic similarity with rat beta 2-microglobulin. Radioimmunoassays specific for the AgB antigen heavy chain and for beta 2-microglobulin, respectively, were used to estimate the contents of these antigens in several tissues. Spleen and thymus exhibit the largest density, while brain is almost devoid of these antigens.

References

Jun 1, 1977·The Journal of Experimental Medicine·T H HansenD H Sachs
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S KvistP A Peterson
Jul 1, 1978·The Journal of Allergy and Clinical Immunology·D H Katz
Apr 8, 1974·Biochimica Et Biophysica Acta·S G Nathenson, S E Cullen
Jun 28, 1974·Nature·L RaskP A Peterson
May 26, 1972·Biochemical and Biophysical Research Communications·M J Hayman, M J Crumpton

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