Properties of scaffolds prepared by fused deposition modeling of poly(hydroxyalkanoates).

International Journal of Biological Macromolecules
Adriana KovalcikAlejandro J Müller

Abstract

Poly(hydroxyalkanoates) are biodegradable and biocompatible polymers suitable for tissue engineering. Fused deposition modeling (FDM) belongs to modern rapid prototyping techniques for the fabrication of scaffolds. In this work, poly(3-hydroxybutyrate (PHB), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBH) were tested for FDM. Thermal and rheological properties of industrial PHAs were compared with poly(lactic acid) (PLA), which is a biodegradable polymer commonly used for FDM. The massive decrease in viscosity and loss of molecular weight of PHB and PHBV precluded their use for FDM. On the other hand, the thermal stability of PHBH was comparable to that of PLA. PHBH scaffolds prepared by FDM exhibited excellent mechanical properties, no cytotoxicity and large proliferation of mouse embryonic fibroblast cells within 96 h. The hydrolytic degradation of PHBH and PLA scaffolds tested in synthetic gastric juice for 52 days confirmed a faster degradation of PHBH than PLA. The decrease in molecular weight confirmed the first-order kinetics with a slightly higher (0.0169 day-1) degradation rate constant for PHBH as compared to the value (0.0107 day-1) obtained for PLA. These ...Continue Reading

Citations

Nov 1, 2020·International Journal of Biological Macromolecules·Salma ShahidZill-I-Huma Nazli
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
May 8, 2021·International Journal of Biological Macromolecules·Adriana KovalcikZdenko Spitalsky
Jul 25, 2021·Polymers·Leire SangronizAntxon Santamaria

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