Properties of single voltage-dependent K+ channels in dendrites of CA1 pyramidal neurones of rat hippocampus

The Journal of Physiology
Xixi Chen, Daniel Johnston

Abstract

Voltage-dependent K(+) channels in the apical dendrites of CA1 pyramidal neurones play important roles in regulating dendritic excitability, synaptic integration, and synaptic plasticity. Using cell-attached, voltage-clamp recordings, we found a large variability in the waveforms of macroscopic K(+) currents in the dendrites. With single-channel analysis, however, we were able to identify four types of voltage-dependent K(+) channels and we categorized them as belonging to delayed-rectifier, M-, D-, or A-type K(+) channels previously described from whole-cell recordings. Delayed-rectifier-type K(+) channels had a single-channel conductance of 19 +/- 0.5 pS, and made up the majority of the sustained K(+) current uniformly distributed along the apical dendrites. The M-type K(+) channels had a single-channel conductance of 11 +/- 0.8 pS, did not inactivate with prolonged membrane depolarization, deactivated with slow kinetics (time constant 100 +/- 6 ms at -40 mV), and were inhibited by bath-applied muscarinic agonist carbachol (10 microm). The D-type K(+) channels had a single-channel conductance of around 18 pS, and inactivated with a time constant of 98 +/- 4 ms at +54 mV. The A-type K(+) channels had a single-channel conductan...Continue Reading

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Citations

Feb 26, 2009·The Journal of Membrane Biology·Mario Vázquez-García, Gloria Reyes-Guerrero
Apr 11, 2006·Pflügers Archiv : European journal of physiology·Meron Gurkiewicz, Alon Korngreen
Jun 1, 2006·Pflügers Archiv : European journal of physiology·Xixi Chen, Daniel Johnston
May 24, 2006·Brain Research·Desheng Wang, Bernard G Schreurs
Jun 3, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mala M ShahDavid A Brown
Nov 19, 2005·Journal of Neurophysiology·Michele MiglioreGiorgio A Ascoli
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Oct 11, 2008·The Journal of Physiology·Jonathon Maffie, Bernardo Rudy
Nov 11, 2008·Journal of Physiology, Paris·W Hamish MehaffeyMaurice J Chacron
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