PMID: 518196Jan 1, 1979Paper

Properties of spermatozoa in relation to their elimination after vasectomy

Archives of Andrology
Y JeanG Bleau

Abstract

Sperm disposal and the formation of sperm granulomas are two related critical aspects of vasectomy which have been studied in man and several animal models. Since mammalian spermatozoa present a keratinoid quality, a comparison was made of the resistance of human and rat spermatozoa. When exposed to dithiothreitol and sodium dodecyl sulfate, human sperm decondense readily while rat sperm resist decondensation for long periods of time. A cooperative effect in the rate of decondensation was observed for human sperm but not for rat sperm. Oxidation of sulfhydryl groups renders human spermatozoa as resistant as rat spermatozoa, indicating that disulfide crosslinks are involved in this resistance. Human spermatozoa constitute a heterogeneous population with respect to sulfhydryl group content, suggesting variations in the state of maturation and/or elimination. The sulfhydryl group content of rat epididymal spermatozoa was similar from one cell to another, suggesting little sperm reabsorption in the epididymis. Human and rat spermatozoa differ in size, resistance to decondensing agents, cooperative effect during decondensation, and content and localization of sulfhydryl groups; these differences can explain why vasectomized rats inv...Continue Reading

References

Jun 1, 1977·Fertility and Sterility·N J Alexander, S S Schmidt
Jun 22, 1978·Biochimica Et Biophysica Acta·Y Marushige, K Marushige
Nov 1, 1976·Journal of Reproduction and Fertility·A Agmo
Feb 1, 1975·Contraception·G A Kinson, R A Layberry
Aug 11, 1975·Fertility and Sterility·M K MacDougallC S Jacobson
Jan 19, 1973·Science·A M SacklerR Schwartz
Oct 1, 1973·The Journal of Urology·A M Kwart, D S Coffey
Jun 1, 1974·Experimental Cell Research·H I Calvin, G Bleau
Aug 1, 1974·Fertility and Sterility·F C DerrickL D Rollins
Oct 13, 1961·Science·J ORBACH

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Citations

Oct 22, 2013·Reproduction, Fertility, and Development·S Arrighi

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