Properties of subependymal cerebrospinal fluid contacting neurones in the dorsal vagal complex of the mouse brainstem.

The Journal of Physiology
Adeline Orts-Del'ImmagineJérôme Trouslard

Abstract

Cerebrospinal fluid (CSF) contacting neurones have been observed in various brain regions such as the hypothalamus, the dorsal nucleus of the raphe and around the central canal (cc) of the spinal cord but their functional role remains unclear. At the level of the spinal cord, subependymal cerebrospinal fluid contacting neurones (S-CSF-cNs) present a peculiar morphology with a soma close to the ependymal layer, a process projecting towards the cc and ending with a bud and a cilium. These neurones were recently shown to express polycystin kidney disease 2-like 1 (PKD2L1 or TRPP3) channels that are members of the polycystin subtype of the transient receptor potential (TRP) channel superfamily and that have been proposed as either chemo- or mechanoreceptors in several tissues. Using immunohistological techniques and whole-cell electrophysiological recordings in brain slices obtained from PKD2L1:EGFP transgenic adult mice, we looked for and determined the functional properties of S-CSF-cNs in the dorsal vagal complex (DVC), a hindbrain structure controlling autonomic functions such as blood pressure, energy balance and food intake. Here, we demonstrate that S-CSF-cNs received GABAergic and/or glycinergic synaptic entries and were al...Continue Reading

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Johansson, P Arhem
Jan 1, 1994·Brain Research Bulletin·Q P Wang, Y Nakai
May 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G SancesarioG Bernardi
Mar 13, 1997·Nature·R WaldmannM Lazdunski
Apr 29, 1998·Microscopy Research and Technique·B Vigh, I Vigh-Teichmann
Feb 21, 2002·Nature Cell Biology·Peter KoulenStefan Somlo
Sep 5, 2002·Nature Reviews. Neuroscience·Yehezkel Ben-Ari
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Nicholas A TritosEleftheria Maratos-Flier
Aug 28, 2004·The Journal of Physiology·Raúl E RussoOmar Trujillo-Cenóz
Nov 19, 2004·The Journal of Biological Chemistry·Manabu MurakamiToshihiko Iijima
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gary J Schwartz
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yoshiro IshimaruHiroaki Matsunami
Aug 25, 2006·Nature·Angela L HuangCharles S Zuker
Nov 7, 2006·Cellular Signalling·Leonidas TsiokasE-Ching Ong
Nov 23, 2006·Toxicon : Official Journal of the International Society on Toxinology·S DiochotM Lazdunski
Sep 7, 2007·Molecular Pharmacology·Xiao-Qing DaiXing-Zhen Chen
Oct 20, 2007·Journal of Neurochemistry·Qiang LiXing-Zhen Chen
Feb 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne BaronEric Lingueglia
Jun 7, 2008·EMBO Reports·Hitoshi InadaMakoto Tominaga
Jul 25, 2008·PLoS Biology·Konstantinos MeletisJonas Frisén
Jul 30, 2008·Pflügers Archiv : European journal of physiology·Takahiro ShimizuBernd Nilius
May 26, 2009·Biochemical and Biophysical Research Communications·Sho IshiiKeiko Abe
Aug 6, 2009·Handbook of Experimental Pharmacology·Peter Holzer
Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolás MarichalRaúl E Russo
Apr 22, 2010·The Journal of Biological Chemistry·Hitoshi KawaguchiMakoto Tominaga
Jun 12, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yoshiro IshimaruKeiko Abe
Sep 3, 2010·Pharmacology & Therapeutics·Emmanuel DevalEric Lingueglia
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas W SherwoodCandice C Askwith
Sep 14, 2011·The Journal of Physiology·Cecilia RealiRaúl E Russo

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Citations

Jan 9, 2013·The Journal of Physiology·K N BrowningR A Travagli
Jan 12, 2016·Current Biology : CB·Kevin FidelinClaire Wyart
Mar 8, 2016·Nature Communications·Urs Lucas BöhmClaire Wyart
Jan 18, 2014·The Journal of Comparative Neurology·Elham JalalvandSten Grillner
May 3, 2016·Current Biology : CB·Elham JalalvandSten Grillner
Jun 28, 2016·ELife·Paul G DeCaenDavid E Clapham
Aug 31, 2016·Current Opinion in Neurobiology·Urs Lucas Böhm, Claire Wyart
Dec 19, 2016·Gastroenterology·Kirsteen N BrowningGuy E Boeckxstaens
Aug 10, 2017·Journal of Neurogenetics·Lydia Djenoune, Claire Wyart
Jun 3, 2016·Nature Reviews. Gastroenterology & Hepatology·R Alberto Travagli, Laura Anselmi
Feb 4, 2016·Development·Yanina L PetraccaGuillermo M Lanuza
Jan 9, 2016·Nature Communications·Elham JalalvandSten Grillner
Feb 12, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Raj K GoyalHiroshi Mashimo
Apr 11, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeremy D BushmanEmily R Liman
Mar 9, 2017·Frontiers in Cell and Developmental Biology·Samantha J EnglandKatharine E Lewis
Aug 21, 2012·The Journal of Physiology·R Alberto Travagli
Sep 27, 2015·Developmental Neurobiology·Aurélie Stil, Pierre Drapeau
Jun 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erica L LittlejohnCarie R Boychuk
Jul 23, 2020·Seminars in Cell & Developmental Biology·Elizabeth A Bearce, Daniel T Grimes

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