PMID: 1195353Oct 16, 1975Paper

Properties of the conductance induced in lecithin bilayer membranes by alamethicin

The Journal of Membrane Biology
G Roy

Abstract

Current-voltage relations have been measured across lecithin bilayers doped with alamethicin molecules. The results show that there are two aspects of the induced conductances, a voltage-dependent and a voltage-independent conductance. Both have been characterized as a function of alamethicin and KCl concentration. The two aspects of the conductances do not show the same changes with those two variables. The voltage-independent conductance is affected very little by changes in KCl concentration, and its dependance on alamethicin concentration reveals that it is produced by two or three alamethicin molecules. The voltage-dependent conductance is shifted by the changes in KCl concentration only when the concentrations are greater than or equal to 100 mM; below 100 mM KCl the slope of the log conductance-voltage curve is also reduced. The effect of changing alamethicin concentration reveals that nine or ten molecules are involved for KCl concentrations larger than 100 mM; if the KCl concentration is less than 100 mM, the effect of changing the alamethicin concentration is reduced. Time-dependent measurements have also been performed; only one time constant was found and it is strongly voltage-dependent. Also a very slow voltage-de...Continue Reading

References

Jan 1, 1974·Journal of Supramolecular Structure·G Baumann, P Mueller
Jan 1, 1974·The Journal of Membrane Biology·G Boheim
May 1, 1972·Quarterly Reviews of Biophysics·D A Haydon, S B Hladky
Dec 31, 1973·The Journal of Membrane Biology·M EisenbergC A Mead
Mar 17, 1972·Biochimica Et Biophysica Acta·L G Gordon, D A Haydon
Feb 24, 1968·Nature·P Mueller, D O Rudin
May 1, 1963·Journal of Theoretical Biology·P Mueller, D O Rudin
Jan 1, 1965·Journal of the American Oil Chemists' Society·W S SINGLETONJ L WHITE
Dec 1, 1972·The Journal of Membrane Biology·R J CherryD E Graham

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Citations

Jan 1, 1994·European Biophysics Journal : EBJ·T RinkG Boheim
Jan 1, 1986·The Journal of Membrane Biology·G MenestrinaG Boheim
Feb 11, 1991·Biochimica Et Biophysica Acta·M PawlakG Schwarz
Feb 1, 1977·Quarterly Reviews of Biophysics·G Ehrenstein, H Lecar
Jan 8, 1981·Biochimica Et Biophysica Acta·H GögeleinR Borghgraef
Jan 1, 1980·Biochemical Pharmacology·C A HermanB B Davis

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