PMID: 9541231Apr 16, 1998Paper

Properties of the (DSS)n triplet repeat domain of rat dentin phosphophoryn

European Journal of Oral Sciences
A VeisJ Malone

Abstract

Phosphophoryns (PPs) are unique aspartic acid and phosphoserine-rich proteins present in all species of dentin. Rat incisor odontoblast cDNA libraries contain messages encoding several acidic phosphorylated, serine-rich proteins. At least two of these share a common C-terminal domain coding region sequence. The polypeptide sequences in the N-terminal direction immediately adjacent to the conserved C-terminal domains of these two proteins (DMP2, DMP3) are distinctly different. In this domain, the DMP2 has extensive sequences of (DSS)n repeats with n as large as 24. DMP3 has fewer and shorter triplet sequences, n = 3, 4. The major rat incisor PPs (90-95 kDa) probably have the (DSS)n>3. We propose that the name phosphophoryn be reserved for the extracellular matrix proteins with these extended repeats. DMPI, although strongly acidic, does not fit this category. If the S residues are phosphorylated and n > 3, conformational energy minimization computations show the (DSS)n sequence to assume a unique extended structure with parallel arrays of carboxylate and phosphate groups which may function as Ca2+ ion interaction edges. The phosphorylation of recombinant DMP2 C-terminal domain by various kinases has been examined. The repeat dom...Continue Reading

Citations

Feb 24, 2011·The Journal of Biological Chemistry·Charles SfeirPrashant N Kumta
Aug 21, 2013·Journal of Tissue Engineering and Regenerative Medicine·Bo ZhongFuzhai Cui
Jan 7, 2006·Calcified Tissue International·S ChangB Clarkson
Feb 28, 2019·Journal of Applied Biomaterials & Functional Materials·Wenyue ZhengLinglin Zhang
Sep 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kunneng LiangJiyao Li
Feb 15, 2001·Nature Genetics·X ZhangY Shen
Feb 4, 2005·American Journal of Medical Genetics. Part a·Juan DongMary MacDougall
Dec 2, 2009·Calcified Tissue International·Daniel K YarbroughWenyuan Shi
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Flavio Meggio, Lorenzo A Pinna
Feb 6, 2014·Journal of Dental Research·Y YangL L Zhang
Apr 17, 2013·The Journal of Biological Chemistry·Sriram RavindranAnne George
Mar 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marta KalkaMagdalena Wojtas
Mar 22, 2001·Biochemistry·J H Waite, X Qin

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