PMID: 3747513Jul 1, 1986Paper

Properties of the estrogen receptors contained in the MtTF4 tumor whose growth is inhibited by estradiol: 17 beta-estradiol, 17 alpha-estradiol and DNA bindings

Journal of Steroid Biochemistry
V AlbaladejoJ Andre

Abstract

The steroid and the DNA bindings of the estrogen receptor of the MtTF4 tumor whose growth is inhibited by estradiol where characterized and compared to those of uterine estrogen receptors. In the tumor cytosol: E protects its binding sites against thermal denaturation, depending on the effects of sodium molybdate upon the dissociation rate of [3H]E at 20 degrees C and the ability of receptor to bind to DNA, the activation (or transformation) process, supposed to be necessary for the full action of estrogen ligand, occurs on estrogen receptor complexes and the calf thymus DNA interacts with estrogen receptor with an affinity similar to that of uterine estrogen receptor. Kinetic and equilibrium studies with 17 alpha-[3H]E both in uterus and tumor indicate that this ligand is fast-associating, fast-dissociating and that its affinity for ER is 2- to 4-fold lower than that of 17 beta-[3H]estradiol one. Competition experiments between 17 beta-[3H]estradiol and the unlabelled 17 alpha epimer reveal, in both uterus and tumor, a time-dependent decrease of the apparent potency of 17 alpha-E to inhibit the binding of [3H]E. It is concluded that the estrogen receptors are very similar in MtTF4 tumor and uterus and the diversity of the resp...Continue Reading

References

Jul 13, 1976·Biochemistry·J AndréH Rochefort
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R R ReedM S Guyer
Mar 21, 1977·Biochemical and Biophysical Research Communications·H Rochefort, F Capony
Jan 1, 1984·Journal of Steroid Biochemistry·M O PharabozJ Andre
May 29, 1980·The New England Journal of Medicine·T J Anglem, S J Camer

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Citations

Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tomoaki SatoTakashige Nishikawa

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