PMID: 6407021Jun 1, 1983Paper

Properties of the major outer membrane protein from Neisseria gonorrhoeae incorporated into model lipid membranes

Proceedings of the National Academy of Sciences of the United States of America
J D YoungZ A Cohn

Abstract

The major outer membrane protein from Neisseria gonorrhoeae was incorporated into artificial planar bilayer membranes by a detergent-dilution procedure. The integrated protein forms voltage-dependent aqueous pores with a minimal pore diameter estimated to be 11 A. A pore of this size suggests a role for this protein in macromolecular sieving at the level of the outer membrane. This protein self-associates preferentially in triplets of three equal unit conductance steps of 130 pS (in 0.1 M NaCl) each. The two-state model may be applied to explain the voltage-dependent conductance. The average lifetime of the open state of single channels is strongly dependent on the applied voltage, the channels shifting to the closed state at higher voltages. The pore is anion selective, differing from porins of other Gram-negative bacteria studied so far but resembling the voltage-dependent anion-selective channel of the outer membrane of mitochondria.

References

Dec 1, 1979·Archives of Biochemistry and Biophysics·E RackerJ Telford
Feb 1, 1977·The Journal of Cell Biology·A C StevenJ P Rosenbusch
Apr 18, 1977·Biochimica Et Biophysica Acta·R A Reithmeier, P D Bragg
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H Schindler, J P Rosenbusch
Dec 1, 1977·The Journal of Cell Biology·A HeleniusJ Kartenbeck
Jul 3, 1975·Biochimica Et Biophysica Acta·R BenzM Montal
Jul 1, 1974·The Journal of Experimental Medicine·C E Frasch, E C Gotschlich
Jun 1, 1974·The Journal of Infectious Diseases·M E WardJ N Robertson
May 1, 1963·Journal of Theoretical Biology·P Mueller, D O Rudin
Jul 1, 1980·The Journal of Cell Biology·R M Garavito, J P Rosenbusch
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H Schindler, J P Rosenbusch
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B L KaganM Colombini
Dec 1, 1982·The Journal of Experimental Medicine·J D YoungZ A Cohn
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C A MannellaJ Frank

❮ Previous
Next ❯

Citations

Jan 1, 1994·Springer Seminars in Immunopathology·Z Fishelson
Jan 1, 1985·Pharmacology & Therapeutics·H Nikaido
Jul 20, 2005·Protein Expression and Purification·Paola MassariLee M Wetzler
Feb 25, 2003·Trends in Microbiology·Paola MassariLee M Wetzler
Nov 1, 1990·Quarterly Reviews of Biophysics·B K Jap, P J Walian
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G P YoungZ A Cohn
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·E R PodackZ A Cohn
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D YoungZ A Cohn
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J D YoungZ A Cohn
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E C GotschlichM Koomey
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B ChristensenD Mauzerall
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N H CarbonettiP F Sparling
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A MauroP Labarca
Sep 1, 1986·The Journal of Experimental Medicine·E C GotschlichA Derman
Nov 1, 1986·The Journal of Experimental Medicine·E J Lytton, M S Blake
Jan 1, 1994·The Journal of Experimental Medicine·R M Steinman, C L Moberg
Sep 9, 1998·The Journal of Experimental Medicine·J P van PuttenJ Carlson
Feb 15, 1993·European Journal of Biochemistry·M Brunen, H Engelhardt
Jan 1, 1985·Antimicrobial Agents and Chemotherapy·F Yoshimura, H Nikaido
Aug 15, 2009·Drugs·Xian-Zhi Li, Hiroshi Nikaido
Jul 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·G LayhT M Buchanan
Jul 1, 1989·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·G Layh-SchmittT M Buchanan
Mar 1, 1989·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·P K KohlT M Buchanan
Nov 1, 1985·Annales De L'Institut Pasteur. Microbiology·E C Gotschlich
Oct 7, 1985·Journal of Theoretical Biology·J D Young
Feb 18, 2004·Biochimica Et Biophysica Acta·Edson J MarquesOleg V Krasilnikov
Jan 1, 1985·CRC Critical Reviews in Biochemistry·R Benz
Mar 20, 2015·Clinical Microbiology Reviews·Xian-Zhi LiHiroshi Nikaido
Jan 1, 1986·Critical Reviews in Microbiology·T Nakae

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved