Properties of unitary potentials generated by intramuscular interstitial cells of Cajal in the murine and guinea-pig gastric fundus

The Journal of Physiology
Elizabeth A H BeckettG David S Hirst

Abstract

Intracellular recordings were made from isolated bundles of the circular muscle layer of mouse and guinea-pig gastric fundus. These preparations displayed an ongoing discharge of membrane noise (unitary potentials), similar to that recorded from similar preparations made from the circular layer of the antrum. Bundles of muscle from the fundus of W/W(V) mice, which lack intramuscular interstitial cells of Cajal (ICC(IM)) lacked the discharge of membrane noise observed in wild-type tissues. When the membrane potential was changed by passing depolarizing or hyperpolarizing current pulses, the discharge of membrane noise was little changed. The membrane noise was unaffected by adding chloride channel blockers; however, agents which buffered the internal concentration of calcium ions reduced the discharge of membrane noise. Treatment of tissues with CCCP, which interferes with the uptake of calcium ions by mitochondria, also reduced the membrane noise and caused membrane hyperpolarization. Similar observations were made on bundles of tissue isolated from the circular layer of the guinea pig antrum. Together the observations indicate that membrane noise is generated by a pathway located in ICC(IM). The properties of this pathway appe...Continue Reading

References

Dec 1, 1975·The Journal of Physiology·M OhbaT Tomita
Dec 1, 1995·The American Journal of Physiology·S M WardK M Sanders
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J BurnsS M Ward
Dec 16, 1998·The Journal of Physiology·E J DickensT Tomita
Jun 22, 1999·The Journal of Physiology·T OrdögK M Sanders
Aug 17, 2001·The Journal of Physiology·G D Hirst, F R Edwards
Aug 16, 2002·The Journal of Physiology·Yoshihiko KitoHikaru Suzuki
Sep 17, 2002·The Journal of Physiology·Elizabeth A H BeckettSean M Ward
Feb 11, 2003·The Journal of Physiology·Dirk F van Helden, Mohammad S Imtiaz
Jun 10, 2003·The Journal of Physiology·G D S Hirst, S M Ward
Jul 26, 2003·The Journal of Physiology·N Teramoto, G D S Hirst
Sep 23, 2003·The Journal of Physiology·Elizabeth A H BeckettSean M Ward

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Citations

Nov 26, 2009·Clinical and Experimental Pharmacology & Physiology·Dirk F van HeldenMohammad S Imtiaz
Aug 2, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A V Bursian
Jul 25, 2009·American Journal of Physiology. Cell Physiology·Nan Ge JinKenton M Sanders
Aug 1, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoshihiko KitoHikaru Suzuki
Jul 16, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko Kito
Oct 15, 2005·The Journal of Physiology·Hikaru HashitaniFrank R Edwards
Dec 17, 2005·The Journal of Physiology·G David S HirstFrank R Edwards
Feb 22, 2012·The Journal of Physiology·Leonie DurninVioleta N Mutafova-Yambolieva
Dec 23, 2004·The Journal of Physiology·F R Edwards, G D S Hirst
Jul 29, 2006·The Journal of Physiology·G David S Hirst, Frank R Edwards
Jun 15, 2004·The Journal of Physiology·G D S HirstF R Edwards
Nov 10, 2009·The FEBS Journal·Mohammad S ImtiazDirk F van Helden
Sep 14, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R G LentleP W M Janssen
Sep 8, 2004·Journal of Pharmacological Sciences·G David S Hirst, Frank R Edwards
Jan 28, 2012·Therapeutic Advances in Gastroenterology·Arthur Beyder, Gianrico Farrugia
Sep 29, 2017·International Journal of Molecular Sciences·Jerry ZhouVincent Ho
Feb 13, 2018·The Journal of Physiology·Tae Sik SungSean M Ward
Aug 5, 2016·Physiology·Kenton M SandersSean M Ward
Oct 21, 2017·Brain : a Journal of Neurology·Hanan E ShamseldinFowzan S Alkuraya
Oct 22, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·R G LentleJ P Chambers
Sep 17, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Abigail S ForrestKenton M Sanders
Sep 1, 2006·American Journal of Physiology. Cell Physiology·Hui ChenKenton M Sanders
Nov 8, 2013·Journal of Neurogastroenterology and Motility·Sang Don Koh, Poong-Lyul Rhee
Jul 6, 2014·Physiological Reviews·Kenton M SandersSang Don Koh
Oct 24, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y ZhangW G Paterson
Sep 3, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Francisco Bautista-Cruz, William G Paterson
Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard T DrummKenton M Sanders
Feb 16, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alberto Corrias, Martin L Buist

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