Properties of Visual Field Defects Around the Monocular Preferred Retinal Locus in Age-Related Macular Degeneration

Investigative Ophthalmology & Visual Science
Jonathan DennissAndrew T Astle

Abstract

To compare microperimetric sensitivity around the monocular preferred retinal locus (mPRL) in age-related macular degeneration (AMD) to normative data, and to describe the characteristics of visual field defects around the mPRL in AMD. Participants with AMD (total n = 185) were either prospectively recruited (n = 135) or retrospectively reviewed from an existing database (n = 50). Participants underwent microperimetry using a test pattern (37 point, 5° radius) centered on their mPRL. Sensitivities were compared to normative data by spatial interpolation, and conventional perimetric indices were calculated. The location of the mPRL relative to the fovea and to visual field defects was also investigated. Location of mPRL varied approximately 15° horizontally and vertically. Visual field loss within 5° of the mPRL was considerable in the majority of participants (median mean deviation -14.7 dB, interquartile range [IQR] -19.6 to -9.6 dB, median pattern standard deviation 7.1 dB [IQR 4.8-9.0 dB]). Over 95% of participants had mean total deviation worse than -2 dB across all tested locations and similarly within 1° of their mPRL. A common pattern of placing the mPRL just foveal to a region of normal pattern deviation was found in 78...Continue Reading

Citations

Sep 23, 2018·Investigative Ophthalmology & Visual Science·Jonathan DennissAndrew T Astle
Aug 25, 2020·Translational Vision Science & Technology·Jason CharngFred K Chen
Jan 11, 2020·Translational Vision Science & Technology·Nicola K CasselsJennifer H Acton
Oct 7, 2020·Progress in Retinal and Eye Research·Maximilian PfauSteffen Schmitz-Valckenberg
Dec 5, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Irina SverdlichenkoLuminita Tarita-Nistor

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