Prophylactic administration of tirofiban for preventing thromboembolic events in flow diversion treatment of intracranial aneurysms.

Journal of Neurointerventional Surgery
Qiaowei WuYing-Kun He

Abstract

Flow diverter (FD) is widely used in the treatment of intracranial aneurysms. However, thromboembolic events (TEs) continue to be the major complications during the periprocedural phase. To evaluate the safety and efficacy of the prophylactic use of tirofiban, combined with the conventional dual antiplatelet therapy (DAT), as a new antiplatelet protocol in patients with intracranial aneurysms treated with FDs. At least 3-5 days before the procedure, daily DAT were administrated to the patients. Tirofiban was administered as an intravenous bolus (5 µg/kg) over a 3 min period during or immediately after FD deployment, followed by a 0.05 µg/kg/min maintenance infusion for 24-48 hours. Periprocedural TEs and hemorrhagic events (HEs) were recorded. A total of 331 patients were included, including 229 (69.2%) who received tirofiban administration (tirofiban group) and 102 (30.8%) who received only DAT (non-tirofiban group). Periprocedural TEs occurred in 12 (3.6%) patients, including eight (7.8%) in the non-tirofiban group and four (1.7%) in the tirofiban group. In multivariate analysis, patients receiving tirofiban administration had significantly lower TEs as compared with those who received only DAT (P=0.004). Balloon angioplasty ...Continue Reading

References

Oct 7, 2004·Journal of the American College of Cardiology·Robert S SchwartzRenu Virmani
Jan 17, 2013·Stroke; a Journal of Cerebral Circulation·Waleed BrinjikjiDavid F Kallmes
Oct 31, 2014·AJNR. American Journal of Neuroradiology·D F KallmesP Lylyk
Oct 22, 2015·Neurosurgery·Nohra ChalouhiDavid M Hasan
Apr 16, 2017·Stroke; a Journal of Cerebral Circulation·Nimer AdeebAjith J Thomas
Jul 13, 2017·International Journal of Stroke : Official Journal of the International Stroke Society·Wang Zi-LiangLi Zhao-Shuo
Dec 2, 2017·Journal of Neurosurgery·Keri S KimAaron M Cook
Jul 6, 2019·Journal of Neurointerventional Surgery·Anna PodlasekMohammed A Almekhlafi

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