PMID: 378140Jun 1, 1979Paper

Prophylactic and preventive antibiotic therapy: timing, duration and economics

Annals of Surgery
H H StoneC A Hooper

Abstract

Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate of potentially contaminated surgery. The need for continuing antibiotic prophylaxis beyond the day of operation, however, has been uncertain. In a prospective, randomized, double-blind study of 220 patients undergoing elective gastric, biliary or colonic surgery, perioperative administration of cefamandole plus five days of placebo was compared to perioperative plus five days of postoperative antibiotic therapy; no significant difference was found between the groups in the rate of infection of wound (6 and 5%, respectively), peritoneum (2% each) and elsewhere (6% and 5%). In another prospective, randomized, nonblind study of 451 determinant cases of 1,624 patients undergoing emergency laparotomy, cephalothin was instituted preoperatively but after peritoneal contamination had occurred (i.e., abdominal trauma, etc.); continued postoperative antibiotic again failed to reduce further the wound and peritoneal infection...Continue Reading

References

May 14, 1977·British Medical Journal·C J StrachanH Norcott
Oct 1, 1977·Southern Medical Journal·H H Stone
Jun 1, 1978·Antimicrobial Agents and Chemotherapy·K R RatzanI Lauredo
Sep 1, 1978·Annals of Surgery·A B KaiserW A Dale
Oct 1, 1976·Annals of Surgery·H H StoneE J Dawkins
Jun 1, 1973·Annals of Surgery·H H Stone, T R Hester
Aug 1, 1973·Archives of Surgery·P J Cruse, R Foord
Aug 1, 1973·Archives of Surgery·S H Chetlin, D W Elliott
Jul 1, 1971·The Journal of Trauma·H H Stone, L D Kolb
Jul 1, 1955·A.M.A. Archives of Surgery·W A ALTEMEIERM VETO

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Citations

Jan 1, 1986·Urological Research·P O Madsen
Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L A Mandell
Mar 1, 1984·Diseases of the Colon and Rectum·F MoesgaardT Justesen
Nov 1, 1989·Irish Journal of Medical Science·P CurleyD Bouchier-Hayes
May 6, 2011·Pediatric Radiology·Mark J Hogan
Feb 1, 1986·American Journal of Surgery·K S ScherC W Jones
Feb 1, 1996·Journal of Clinical Epidemiology·M ThomasA Joseph
Jan 8, 2000·The Surgical Clinics of North America·R Ferrada, D Birolini
Mar 25, 2005·British Dental Journal·M V MartinP Hardy
Oct 30, 1986·The New England Journal of Medicine·A B Kaiser
Feb 22, 2003·Surgical Infections·D E Fry
May 4, 2005·Surgical Infections·Donald E Fry, UNKNOWN Surgical Infection Society--Europe
Feb 17, 2009·Surgical Infections·Donald E Fry
Dec 7, 2011·Surgical Infections·Donald E Fry
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Sep 1, 1980·Annals of Surgery·H A PittD Bouchier-Hayes
Nov 1, 1984·Annals of Surgery·L O GentryG L Jordan
Apr 5, 2002·Plastic and Reconstructive Surgery·John A PerrottiJames E Zins
Jun 12, 2008·Implant Dentistry·Randolph R Resnik, Carl Misch
Jun 12, 1998·The Australian and New Zealand Journal of Surgery·M McDonaldA Forbes
Jul 1, 1995·Veterinary Surgery : VS·S W Petersen, E Rosin
Jun 1, 1981·Postgraduate Medical Journal·R S CrotonL A Eilon
Apr 15, 2010·Patient Safety in Surgery·Eefje N de VriesMarja A Boermeester
Jul 17, 2004·The Journal of Oral Implantology·Harold F MorrisPaul M Lambert
Jun 18, 2010·The Journal of Oral Implantology·Alfonso CaiazzoFederico Brugnami
Mar 12, 2002·Annals of Periodontology·D M LaskinJ W Olson
Oct 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensUNKNOWN Infectious Diseases Society of America
Jun 11, 1991·Journal of Cardiac Surgery·K S Ulicny, L F Hiratzka
Jun 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensJames C Wade
Dec 21, 2013·The Journal of Arthroplasty·Erik HansenKoji Yamada
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Isabelle SourrouilleAlain Sauvanet
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T de BaèreC Patriarche
Oct 6, 2012·Revue de stomatologie et de chirurgie maxillo-faciale·M SixouJ Quéro
Jun 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·J Mark RyanTony P Smith
Nov 24, 2011·Thoracic Surgery Clinics·Stephanie H Chang, Alexander S Krupnick

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