Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice

Antimicrobial Agents and Chemotherapy
J P WongM Kende

Abstract

Polyriboinosinic-polyribocytidylic acid [poly(IC.LC)] was evaluated for its prophylactic and therapeutic efficacies against respiratory influenza A virus infection in mice. Two doses of poly(IC.LC) (1 mg/kg of body weight per dose) administered intranasally within 12 days prior to infection with 10 50% lethal doses of mouse-adapted influenza A/PR/8 virus fully protected the mice against the infection. Determination of virus titers by hemagglutination and plaque assays showed more than a 2-log10 decrease in virus titers in lung homogenates of pretreated mice compared with those in the lungs of the nonpretreated group. Treatment of infected mice with poly(IC.LC) resulted in a modest (40%) survival rate. These results suggest that poly(IC.LC) provides a highly effective prophylaxis against respiratory influenza A virus infection in mice.

Citations

May 21, 2005·Life Sciences·Noé Alvarado-VásquezHeberto Alcázar-Montenegro
Apr 23, 2005·Virus Research·Ryszard MiedzybrodzkiAndrzej Gorski
Dec 30, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marina S BoukhvalovaJorge C G Blanco
Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Camila C DiasMarvin J Grubman
Nov 24, 2012·Journal of Virology·Luis Martínez-GilPeter Palese
Aug 17, 2005·Journal of Virology·Patricia V AguilarScott C Weaver
May 23, 2006·Emerging Infectious Diseases·Ken Alibek, Ge Liu
Mar 28, 2009·International Journal of Molecular Sciences·Mary E Christopher, Jonathan P Wong
Jan 12, 2013·Veterinary Immunology and Immunopathology·Michael St PaulShayan Sharif
Sep 25, 2015·Future Medicinal Chemistry·Jonathan P Wong
Nov 14, 2006·Brain, Behavior, and Immunity·Tim R TraynorJames M Krueger
May 14, 2005·Antiviral Chemistry & Chemotherapy·Michael Markosian, Robyn M Hyde
Jun 6, 2014·Reproductive Sciences·Renju S RajMark Phillippe
Jul 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergey A TarasovOleg I Epstein
Dec 10, 2016·Critical Reviews in Microbiology·Beatrice Ellen TyrrellNicole Zitzmann
Sep 25, 2018·Future Virology·Victor CasanovaPeter G Barlow

Related Concepts

Poly ICLC, sodium salt
Administration, Intranasal
Metazoa
Antiviral Agents
Ruspol
Injections, Intraperitoneal
Interferon Inducers
Interferons
Lung
Swine Influenza

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.