Prophylactic and therapeutic efficacy of the epitope vaccine CTB-UA against Helicobacter pylori infection in a BALB/c mice model

Applied Microbiology and Biotechnology
Le GuoTao Xi

Abstract

Epitope vaccine based on the enzyme urease of Helicobacter pylori is a promising option for prophylactic and therapeutic vaccination against H. pylori infection. In our previous study, the epitope vaccine CTB-UA, which was composed of the mucosal adjuvant cholera toxin B subunit (CTB) and an epitope (UreA₁₈₃₋₂₀₃) from the H. pylori urease A subunit (UreA) was constructed. This particular vaccine was shown to have good immunogenicity and immunoreactivity and could induce specific neutralizing antibodies, which exhibited effectively inhibitory effects on the enzymatic activity of H. pylori urease. In this study, the prophylactic and therapeutic efficacy of the epitope vaccine CTB-UA was evaluated in a BALB/c mice model. The experimental results indicated that oral prophylactic or therapeutic immunization with CTB-UA significantly decreased H. pylori colonization compared with oral immunization with PBS. The results also revealed that the protection was correlated with antigen-specific IgG, IgA, and mucosal secretory IgA antibody responses. CTB-UA may be a promising vaccine candidate for the control of H. pylori infection.

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Citations

Dec 29, 2013·Applied Microbiology and Biotechnology·Le GuoYingying Xing
Sep 28, 2012·European Journal of Pediatrics·Deniz Ertem
Dec 5, 2015·Frontiers in Plant Science·Mohammad T WaheedAndreas G Lössl
Sep 18, 2013·Helicobacter·Manuel KochSteven F Moss
Dec 17, 2015·Therapeutic Advances in Vaccines·Kari WiedingerConstantine Bitsaktsis
Mar 25, 2015·Toxins·Keegan J BaldaufNobuyuki Matoba
Jun 13, 2019·Journal of Cellular Physiology·Masoud KeikhaMohsen Karbalaei
Aug 19, 2014·World Journal of Gastroenterology : WJG·Oya Yucel
Sep 19, 2014·World Journal of Gastroenterology : WJG·Florian Anderl, Markus Gerhard
Aug 27, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hadi Maleki KakelarYadollah Omidi
Feb 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Enrico MalitoVega Masignani

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