Prophylactic antibiotics before cord clamping in cesarean delivery: a systematic review

Acta Obstetricia Et Gynecologica Scandinavica
Claudia BolligChristine Schmucker

Abstract

The number of clinical trials investigating the optimal timing of prophylactic antibiotics in cesarean section has increased rapidly over the last few years. We conducted a systematic review to inform up-to-date evidence-based guidelines to prevent postpartum infectious morbidity in the mother and rule out any safety issues related to antepartum antibiotic exposure in infants. Four bibliographic databases were searched for published reports of trials. Ongoing or unpublished studies were searched in Clinicaltrials.gov and the World Health Organization registry platform. Randomized controlled trials comparing antibiotic prophylaxis before and after cord clamping in cesarean section were eligible. Maternal and neonatal outcomes were assessed, and certainty of evidence graded. In total, 18 randomized controlled trials met the inclusion criteria. Those women who received antibiotics preoperatively were 28% (relative risk 0.72, 95% confidence interval 0.56-0.92, nine studies, 4342 women, high quality of evidence) less likely to show infectious morbidity as compared with those who received antibiotics after cord clamping. The risk of endomyometritis and/or endometritis was reduced by 43% (relative risk 0.57, 95% confidence interval 0....Continue Reading

References

Jan 1, 1997·The Journal of Maternal-fetal Medicine·J R WaxJ F Smith
Jan 5, 2002·Obstetrics and Gynecology·T Fiore MitchellR G Faix
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 23, 2005·American Journal of Obstetrics and Gynecology·Brad D ThigpenJohn C Morrison
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Maged M CostantineGeorge R Saade
Nov 27, 2008·Archives of Gynecology and Obstetrics·Gokhan YildirimYavuz Ceylan
Mar 21, 2009·Obstetrics and Gynecology·Alan T N TitaWilliam W Andrews
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jul 31, 2009·Acta Obstetricia Et Gynecologica Scandinavica·Rita Andersen LethMette Nørgaard
Sep 22, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·E BoselliB Allaouchiche
Nov 6, 2010·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Julie van SchalkwykUNKNOWN Society of Obstetricians and Gynaecologists of Canada Infectious Diseases Committee
Dec 17, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
May 25, 2011·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists
Dec 3, 2011·American Journal of Perinatology·George A MaconesRoxane Rampersad
Nov 7, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·H Baaqeel, R Baaqeel
Feb 12, 2013·BMC Research Notes·Bashier OsmanIshag Adam
Mar 8, 2013·American Journal of Obstetrics and Gynecology·Joshua D DahlkeSuneet P Chauhan
May 25, 2013·Journal of Perinatology : Official Journal of the California Perinatal Association·C FrancisE A Strand
Jul 24, 2013·The Journal of Obstetrics and Gynaecology Research·Nabendu BhattacharjeeSamir Chandra Ghoshroy
Jul 31, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mohamed KandilWael Gaber

❮ Previous
Next ❯

Citations

May 31, 2018·Current Opinion in Infectious Diseases·Geeta SoodJeanne S Sheffield
Aug 23, 2018·Obstetrics and Gynecology·UNKNOWN Committee on Practice Bulletins-Obstetrics
May 18, 2018·F1000Research·Unyime Ituk, Ashraf S Habib
Sep 24, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·Acr WintherEcl Løkkegaard
Sep 10, 2020·Frontiers in Pediatrics·Siobhan BrushettAlexandra Zhernakova
Jan 26, 2021·Anesthesiology Research and Practice·Emily S ReiffKarthik Raghunathan
Jul 18, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sidsel Høgh-PoulsenPaul Bryde Axelsson
Aug 31, 2021·Seminars in Perinatology·Stefan C KaneCaroline A Crowther

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.