Prophylactic antibiotics in open distal phalanx fractures: systematic review and meta-analysis

The Journal of Hand Surgery, European Volume
D MetcalfeH M Hedley

Abstract

A systematic review was conducted on 30 December 2014 to determine whether prophylactic antibiotics reduce the risk of superficial infection and osteomyelitis following open distal phalanx fractures. Four randomized controlled trials (353 fractures) were suitable for meta-analysis. There was no statistically significant difference between rates of superficial infection in the two groups. This finding persisted when only the two most recent and highest quality trials were included. There were no reported cases of osteomyelitis in the pooled dataset, despite patients with 164 fractures not receiving antibiotics. These results fail to show any effect of prophylactic antibiotics on the rate of superficial infections following open distal phalanx fractures. The focus of treatment should be on prompt irrigation and debridement rather than administration of prophylactic antibiotics.

References

May 1, 1991·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S P ChowC Crosby
Sep 1, 1990·The Journal of Hand Surgery·M D SuprockJ D Lubahn
May 1, 1987·Injury·T IpsenT Barfred
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jan 1, 1969·Acta Orthopaedica Scandinavica. Supplementum·J Schatzker, P I Brånemark
Dec 10, 1999·Emergency Medicine Clinics of North America·B P Harrison, M W Hilliard
May 1, 1956·Annals of Human Genetics·J B HALDANE
Mar 19, 2008·Pediatric Emergency Care·Caroline AltergottAlan L Nager
Mar 23, 2010·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Nakul KainPaul McArthur
Apr 13, 2011·British Journal of Clinical Pharmacology·Bernard Y-H Thong, Teck-Choon Tan
May 31, 2011·The Journal of Hand Surgery·James P Higgins
Apr 17, 2014·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·S P Ryan, V Pugliano
Oct 4, 2014·Frontiers in Public Health·Carolyn Anne MichaelMaurizio Labbate

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Citations

Feb 22, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Nofar Ben BasatRonit Wollstein
May 26, 2020·Hand : Official Journal of the American Association for Hand Surgery·Eugene Warnick, Asif M Ilyas
Nov 18, 2020·Hand Clinics·Matthew E WellsJohn C Dunn
Apr 24, 2021·Plastic and Reconstructive Surgery·Nishant Ganesh Kumar, Kevin C Chung
Jul 9, 2021·Journal of Orthopaedic Surgery and Research·Yung-Cheng ChiuJui-Ting Hsu

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