Prophylactic Antibiotics in Prostate Biopsy: A Meta-Analysis Based on Randomized Controlled Trials

Surgical Infections
Lu YangQiang Wei

Abstract

Despite frequent use of prophylactic antibiotics for patients undergoing transrectal prostate biopsy (TRPB), the incidences of urinary tract infection (UTI) and bacteria resistance are increasing. The aim of this study is to evaluate the current regimen of antimicrobial prophylaxis in TRPB. A systematic search of PubMed(®), Embase(®), and the Cochrane Library was performed to identify all randomized controlled trials (RCT) related to the effects of antibiotic prophylaxis for TRPB. The outcomes included bacteriuria, bacteremia, drug-resistant bacteria on urine/blood culture, fever, UTI, sepsis, and hospitalization. A total of 22 RCTs with 3846 patients were identified and included. Nine trials analyzed antibiotics versus placebo/no treatment, with all outcomes substantially favoring antibiotic use (p<0.05), including bacteriuria (risk ratio [RR] 0.25, 95% confidence interval [CI] 0.15-0.42), bacteremia (RR 0.67, 95% CI 0.49-0.92), fever (RR 0.39, 95% CI 0.23-0.64), UTI (RR 0.37, 95% CI 0.22-0.62), and hospitalization (RR 0.13, 95% CI 0.03-0.55). There were no substantial differences between long-course versus short-course treatment and single versus multiple dose respectively, except for a greater risk of bacteriuria for short-c...Continue Reading

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Citations

Nov 25, 2016·Der Urologe. Ausg. A·L Schneidewind
Mar 28, 2021·World Journal of Urology·Rebecca S SteinbergChristopher Filson
Dec 7, 2018·European Urology Focus·Adrian PilatzBenjamin Pradere
Apr 21, 2021·Urology·Lydia GlickMark J Mann
May 28, 2021·Clinical Ophthalmology·Asad F DurraniDavid N Zacks

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Methods Mentioned

BETA
biopsy
urine collection
biopsies

Software Mentioned

QUOROM

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