PMID: 9188113Jan 1, 1997Paper

Prophylactic antiemetics in children undergoing tonsillectomy: high-dose vs low-dose ondansetron

Paediatric Anaesthesia
W M Splinter, E J Rhine

Abstract

This randomized, double-blind study assessed the impact of two different doses of intraoperative ondansetron on vomiting following tonsillectomy in 240 preadolescent children in a day care surgical setting. After anaesthesia was established by inhalation with N2O/ halothane or intravenously with propofol, the subjects were administered the study drug (50 or 150 micrograms.kg-1 ondansetron, maximum dose 8 mg). Anaesthesia was maintained with N2O/ halothane. The greater dose of ondansetron (150 micrograms.kg-1) had a lower incidence (36% vs 52%) of postoperative vomiting (P = 0.01). In-hospital emesis was not a problem with only 14% of the subjects vomiting. Eight patients sought medical attention for vomiting after discharge from hospital. In-conclusion, 150 micrograms.kg-1 ondansetron is a more effective prophylactic antiemetic than 50 micrograms.kg-1 ondansetron among children undergoing elective tonsillectomy.

Citations

May 29, 1998·Journal of Clinical Anesthesia·E D Figueredo, L G Canosa
Jul 5, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Ayla A KabalakNermin Gogus
Sep 3, 1999·Clinical Otolaryngology and Allied Sciences·A Drake-Lee, S Harris
Feb 13, 2007·Paediatric Drugs·Anthony L Kovac
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Jan 13, 1999·Clinical Otolaryngology and Allied Sciences·A Drake-Lee, M Stokes
Jun 20, 2021·Clinical Pharmacology and Therapeutics·Tjitske M van der ZandenSaskia N de Wildt

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