PMID: 9447850Feb 3, 1998Paper

Prophylactic atenolol reduces postoperative myocardial ischemia. McSPI Research Group

Anesthesiology
A WallaceD T Mangano

Abstract

Perioperative myocardial ischemia occurs in 20-40% of patients at risk for cardiac complications and is associated with a ninefold increase in risk for perioperative cardiac death, myocardial infarction, or unstable angina, and a twofold long-term risk. Perioperative atenolol administration reduces the risk of death for as long as 2 yr after surgery. This randomized, placebo-controlled, double-blinded trial tested the hypothesis that perioperative atenolol administration reduces the incidence and severity of perioperative myocardial ischemia, potentially explaining the observed reduction in the risk for death. Two-hundred patients with, or at risk for, coronary artery disease were randomized to two study groups (atenolol and placebo). Monitoring included a preoperative history and physical examination and daily assessment of any adverse events. Twelve-lead electrocardiography (ECG), three-lead Holter ECG, and creatinine phosphokinase with myocardial banding (CPK with MB) data were collected 24 h before until 7 days after surgery. Atenolol (0, 5, or 10 mg) or placebo was administered intravenously before induction of anesthesia and every 12 h after operation until the patient could take oral medications. Atenolol (0, 50, or 100 ...Continue Reading

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Citations

Jan 14, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Homer Yang, W Scott Beattie
Feb 1, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Samuel ArmaniousFrances Chung
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