Prophylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery

Acta Anaesthesiologica Scandinavica
D K ChoiI C Choi

Abstract

The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery. A total of 320 patients scheduled for elective cardiac surgery were enrolled. Patients were randomly assigned to one of four treatment regimens (n=80 in each group): no prophylactic antiemetics (group P); intravenous (i.v.) ondansetron 4 mg at the end of surgery and 12 mg added to PCA (group O); i.v. ramosetron 0.3 mg at the end of surgery and no antiemetics added to PCA (group R1); and i.v. ramosetron 0.3 mg at the end of surgery and 0.6 mg added to PCA (group R2). The incidence of PONV during the 48-h post-operative period was lower in groups O (46%), R1 (54%), and R2 (35%) compared with group P (71%, P<0.001). The incidence and severity of nausea were lower in groups O, R1, and R2 than in group P during the 24-h post-operative period, whereas the incidence and severity of nausea during 24-48 h after surgery were lower in groups O and R2, but not in group R1, than in group P. Compared with group P (53%), the frequency of rescue antiemetic usage was significantly lower in groups O (34%) and R2 (29%), but not in gr...Continue Reading

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Citations

Aug 26, 2014·Heart & Lung : the Journal of Critical Care·Jo-Ann V SawatzkyRakesh C Arora
Jun 9, 2015·Complementary Therapies in Medicine·Marie CookeClaire Rickard
May 20, 2016·British Journal of Clinical Pharmacology·Yong-Hun LeeGyu-Jeong Noh
Dec 8, 2011·Korean journal of anesthesiology·Won Oak KimHae Keum Kil
Jan 20, 2015·Korean journal of anesthesiology·Yoo-Jin KangJong-Man Kang
Feb 1, 2013·Anesthesiology·Jeffrey L ApfelbaumUNKNOWN American Society of Anesthesiologists Task Force on Postanesthetic Care
Jul 31, 2019·BioMed Research International·Yanghyun Kim, Sungwoo Kang
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Sep 16, 2018·The American Journal of Emergency Medicine·Tim MontriefBrit Long
Sep 14, 2021·Current Medical Research and Opinion·Christine H Meyer-FrießemAndreas Baumann

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