Prophylactic control of simian hemorrhagic fever in monkeys by an interferon inducer, polyriboinosinic-polyribocytidylic acid-poly-L-lysine

The Journal of Infectious Diseases
H B LevyJ Rice

Abstract

A nuclease-resistant complex of polyriboinosinic-polyribocytidylic acid containing poly-L-lysine and carboxymethylcellulose was used as prophylactic treatment of simian hemorrhagic fever in rhesus monkeys. This infection has proven uniformly fatal to more than 50 monkeys. Treatment 8 hr before infection and repeatedly thereafter completely prevented the development of viremia and death. Untreated animals died before development of antibodies to the virus. None of the treated animals developed antibody to the virus, a fact which suggested that viral growth was essentially completely blocked by the compound.

Citations

Aug 29, 2012·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Camila C DiasMarvin J Grubman
Jan 1, 1981·Pharmacology & Therapeutics·E R Kern, L A Glasgow
Jan 1, 1980·Pharmacology & Therapeutics·W M Shannon, F M Schabel
May 21, 2005·Journal of Neuroimmunology·Zhiren ZhangHermann J Schluesener
May 14, 2005·Antiviral Chemistry & Chemotherapy·Michael Markosian, Robyn M Hyde
Jan 1, 1981·Journal of Interferon Research·G P LampsonM R Hilleman
Jan 1, 1981·Archives of Dermatological Research·D A Stringfellow
Jun 16, 1992·Annals of the New York Academy of Sciences·M Kende
Jan 2, 1979·European Journal of Biochemistry·E de Clercq

Related Concepts

Metazoa
Anthropoidea
Antibodies, Viral
Antibody Formation
Cethylose
Sabia virus
Hemorrhagic Fevers, Viral
Interferon Inducers
Macaca mulatta
Monkey Diseases

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.